PDF(Pubmed)
Abstract：
In this overview, we seek to appraise recent experimental and observational studies investigating THC and its potential role as adjunctive therapy in various medical illnesses. Recent clinical trials are suggestive of the diverse pharmacologic potentials for THC but suffer from small sample sizes, short study duration, failure to address tolerance, little dose variation, ill-defined outcome measures, and failure to identify and/or evaluate confounds, all of which may constitute significant threats to the validity of most trials. However, the existing work underscores the potential therapeutic value of THC and, at the same time, calls attention to the critical need for better-designed protocols to fully explore and demonstrate safety and efficacy. In the most general sense, the present brief review illuminates some intriguing findings about THC, along with the basic threats to the validity of the research that supports those findings. The intent is to highlight existing generic weaknesses in the existing randomized controlled trial literature and, most importantly, provide guidance for improved clinical research.
摘要：
在本概述中,我们试图评估最近研究THC的实验和观察性研究及其在各种医学疾病中作为辅助治疗的潜在作用.最近的临床试验表明THC具有多种药理潜力，但样本量较小，研究持续时间短，未能解决宽容问题，剂量变化很小，不明确的结果衡量标准，以及未能识别和/或评估混淆，所有这些都可能对大多数试验的有效性构成重大威胁.然而,现有的工作强调了THC的潜在治疗价值，同时,呼吁人们注意迫切需要更好设计的方案，以充分探索和证明安全性和有效性。在最普遍的意义上，本简要综述阐明了一些关于THC的有趣发现，以及支持这些发现的研究有效性的基本威胁。目的是突出现有随机对照试验文献中现有的一般性弱点，最重要的是,为改进临床研究提供指导。
