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Abstract：
(1) Background: Paraphilic disorders, marked by intense sexual fantasies and behaviors, present formidable challenges. This review addresses concerns fueled by scandals and child abuse. Emphasizing paraphilias\' complexity, it systematically reviews the pharmacotherapy literature, aiming to enhance understanding and guide future research. (2) Methods: A comprehensive search from 1990 to 2023 across major databases identified 28 relevant English-language studies. Inclusion criteria focused on adult pharmacotherapy for paraphilias, and results were evaluated using the Newcastle-Ottawa Scale. (3) Results: Synthesizing data from selected studies, diverse treatments such as SSRIs and antiandrogens were analyzed, revealing variable effectiveness and side effect profiles. Poor quality of the current literature has been reported. (4) Conclusions: Highlighting the pivotal role of the serotonergic system, this review underscores the efficacy of SSRIs and androgen deprivation therapy. GnRH analog-associated side effects and the importance of a combined assessment approach are discussed. Critical insights contribute to understanding and ethical considerations in paraphilic disorders.
摘要：
（1）背景：嗜血性疾病，以强烈的性幻想和行为为标志，带来了巨大的挑战。这篇评论解决了丑闻和虐待儿童引发的担忧。强调亲缘关系的复杂性，它系统地回顾了药物治疗文献，旨在增进理解并指导未来的研究。（2）方法：从1990年到2023年，对主要数据库进行了全面搜索，确定了28项相关的英语研究。纳入标准集中在成人药物治疗上，结果采用纽卡斯尔-渥太华量表进行评估。(3)结果：综合选定研究的数据，分析了SSRIs和抗雄激素等多种治疗方法，揭示可变的有效性和副作用概况。目前已有文献报道质量差。（4）结论：突出5-羟色胺能系统的关键作用，这篇综述强调了SSRIs和雄激素剥夺治疗的疗效。讨论了GnRH类似物相关的副作用以及联合评估方法的重要性。批判性的见解有助于理解和道德方面的考虑。
