PDF(Pubmed)
Abstract：
BACKGROUND: Among all studies describing COVID-19 clinical features during the first wave of the pandemic, only a few retrospective studies have assessed the correlation between olfac-tory dysfunction (OD) and the evolution of disease severity. The main aim was to assess whether OD is a predictive factor of COVID-19 severity based on the patient\'s medical management (outpa-tient care, standard hospital admission, and ICU admission).
METHODS: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing. During the first wave of the pandemic, from 6 April to 11 May 2020, all patients tested positive for COVID-19 confirmed by RT-PCR underwent two follow-up ENT consultations within 10 days of symptom onset. The main outcome measures were the evolution of medical management (out-patient care, standard hospital admission, and ICU admission) at diagnosis and along the clinical course of COVID-19 disease.
RESULTS: Among 481 patients included, the prevalence of OD was 60.7%, and it affected mostly female patients (74.3%) under 65 years old (92.5%), with fewer comor-bidities than patients with normal olfactory function. Here, 99.3% (290/292) of patients with OD presented with non-severe COVID-19 disease. Patients reporting OD were significantly less hospi-talized than the ones managed as outpatients, in either a standard medical unit or an ICU. Conclu-sions: As regards the clinical course of COVID-19 disease, OD could predict a decreased risk of hospitalization during the first wave of the pandemic.
METHODS: A national, prospective, mul-ticenter cohort study was conducted in 20 public hospitals and a public center for COVID-19 screen-ing. During the first wave of the pandemic, from 6 April to 11 May 2020, all patients tested positive for COVID-19 confirmed by RT-PCR underwent two follow-up ENT consultations within 10 days of symptom onset. The main outcome measures were the evolution of medical management (out-patient care, standard hospital admission, and ICU admission) at diagnosis and along the clinical course of COVID-19 disease.
RESULTS: Among 481 patients included, the prevalence of OD was 60.7%, and it affected mostly female patients (74.3%) under 65 years old (92.5%), with fewer comor-bidities than patients with normal olfactory function. Here, 99.3% (290/292) of patients with OD presented with non-severe COVID-19 disease. Patients reporting OD were significantly less hospi-talized than the ones managed as outpatients, in either a standard medical unit or an ICU. Conclu-sions: As regards the clinical course of COVID-19 disease, OD could predict a decreased risk of hospitalization during the first wave of the pandemic.
摘要：
背景：在描述第一波大流行期间COVID-19临床特征的所有研究中，只有少数回顾性研究评估了嗅觉功能障碍(OD)与疾病严重程度演变之间的相关性.主要目的是根据患者的医疗管理(门诊护理，标准入院，和ICU入院)。
方法：国家，prospective,多中心队列研究在20家公立医院和一个公共COVID-19筛查中心进行。在第一波大流行期间，从2020年4月6日至5月11日,经RT-PCR证实COVID-19检测呈阳性的所有患者在症状出现后10天内接受了两次耳鼻喉科随访咨询.主要结果指标是医疗管理的演变(门诊护理，标准入院，和ICU入住）在COVID-19疾病的诊断和临床过程中。
结果：在481名患者中，OD的患病率为60.7%，它影响了大多数65岁以下的女性患者（74.3％）（92.5％），与嗅觉功能正常的患者相比，合并症较少。这里,99.3%(290/292)的OD患者表现为非重度COVID-19疾病。报告OD的患者的住院率明显低于门诊患者，在标准医疗单位或ICU。结论：关于COVID-19疾病的临床病程，OD可以预测在第一波大流行期间住院风险降低。
方法：国家，prospective,多中心队列研究在20家公立医院和一个公共COVID-19筛查中心进行。在第一波大流行期间，从2020年4月6日至5月11日,经RT-PCR证实COVID-19检测呈阳性的所有患者在症状出现后10天内接受了两次耳鼻喉科随访咨询.主要结果指标是医疗管理的演变(门诊护理，标准入院，和ICU入住）在COVID-19疾病的诊断和临床过程中。
结果：在481名患者中，OD的患病率为60.7%，它影响了大多数65岁以下的女性患者（74.3％）（92.5％），与嗅觉功能正常的患者相比，合并症较少。这里,99.3%(290/292)的OD患者表现为非重度COVID-19疾病。报告OD的患者的住院率明显低于门诊患者，在标准医疗单位或ICU。结论：关于COVID-19疾病的临床病程，OD可以预测在第一波大流行期间住院风险降低。
