PDF(Pubmed)
Abstract：
Background and Objectives: Periodontitis is marked by the destruction of alveolar bone. Sclerostin (SOST) and dickkopf-1 (DKK-1) act as inhibitors of the Wingless-type (Wnt) signaling pathway, a key regulator of bone metabolism. Recent studies have suggested that statins play a role in bone resorption and formation by influencing Wnt signaling. The aim of this study was to determine the levels of SOST and DKK-1 in periodontal patients with and without peroral statins treatment in their therapy. Materials and Methods: A total of 79 patients with diagnosed periodontitis were divided into two groups: 39 patients on statin therapy (SP group) and 40 patients without statin therapy as a control group (P group). The periodontal clinical examination probing (pocket) depth (PD) and gingival recession (GR) were measured, and approximal plaque was detected, while vertical and horizontal bone resorption was measured using a panoramic radiograph image. Clinical attachment loss (CAL) values were calculated using PD and GR values. Gingival crevicular fluid (GCF) was collected and used for measuring SOST and DKK-1 levels. A questionnaire was used to assess lifestyle habits and statin intake. Patients\' medical records were used to obtain biochemical parameters. Results: There was no significant difference in sclerostin concentration between the SP and P group. DKK-1 values were significantly higher in the SP group compared to the control group (p = 0.04). Also, PD (p = 0.001) and GR (p = 0.03) were significantly higher in the SP group. The level of DKK-1 had a positive relationship with the PD, the greater the PD, the higher the level of DKK-1 (Rho = 0.350), while there was no significant association with other parameters. Conclusions: Peroral statins in periodontal patients are associated with GCF levels of DKK-1 but not with sclerostin levels.
摘要：
背景与目的：牙周炎以牙槽骨破坏为标志。硬化蛋白（SOST）和dickkopf-1（DKK-1）作为无翼型（Wnt）信号通路的抑制剂，骨代谢的关键调节剂。最近的研究表明，他汀类药物通过影响Wnt信号在骨吸收和形成中起作用。这项研究的目的是确定在接受和不接受口服他汀类药物治疗的牙周患者中SOST和DKK-1的水平。材料与方法：将79例确诊为牙周炎的患者分为两组：39例接受他汀类药物治疗的患者（SP组）和40例未接受他汀类药物治疗的患者（P组）。测量牙周临床检查探查（口袋）深度（PD）和牙龈退缩（GR），检测到近似的斑块，而垂直和水平骨吸收是使用全景X射线图像测量的。使用PD和GR值计算临床附着丧失(CAL)值。收集牙龈沟液（GCF）并用于测量SOST和DKK-1水平。使用问卷评估生活习惯和他汀类药物的摄入量。患者的医疗记录用于获取生化参数。结果：SP组和P组硬化蛋白浓度无明显差异。SP组的DKK-1值显著高于对照组(p=0.04)。此外，SP组的PD（p=0.001）和GR（p=0.03）明显较高。DKK-1水平与PD呈正相关,PD越大,DKK-1的水平越高（Rho=0.350），而与其他参数无显著关联。结论：牙周患者口服他汀类药物与GCF中DKK-1水平相关，但与硬化素水平无关。
