PDF(Pubmed)
Abstract：
Zambia\'s adult HIV prevalence is high at 11% and faces challenges in achieving UNAIDS 95-95-95 targets for HIV, with a national viral load suppression of 86.2% falling short of the required 95%. North-Western Province has the lowest viral load suppression at 77.5%. Our study investigated the role of an integrated sample referral system in optimizing HIV viral load coverage and Early Infant Diagnosis turnaround time in the province. Using electronic data from the DISA Laboratory Information System and Smartcare, a retrospective cross-sectional analysis was conducted, involving 160,922 viral load and Early Infant Diagnosis results. The chi-square test and multiple linear regression were used for analysis. Following the implementation of the integrated sample referral system, viral load coverage consistently increased monthly (p < 0.001), Early Infant Diagnosis turnaround time improved by 47.7%, and sample volume increased by 25%. The study identifies associations between various factors and testing outcomes. These findings demonstrate improvements in viral load coverage and the Early Infant Diagnosis turnaround time and suggest targeting modifiable factors to further optimize the referral system. We recommend continued strengthening of the referral system and more deliberate demand-creation implementation strategies.
摘要：
赞比亚的成人艾滋病毒感染率高达11%，在实现艾滋病规划署95-95-95目标方面面临挑战。全国86.2%的病毒载量抑制低于所需的95%。西北省的病毒载量抑制最低，为77.5％。我们的研究调查了综合样本转诊系统在优化该省HIV病毒载量覆盖率和早期婴儿诊断周转时间中的作用。使用来自DISA实验室信息系统和Smartcare的电子数据，进行了回顾性横断面分析，涉及160,922个病毒载量和早期婴儿诊断结果。采用卡方检验和多元线性回归进行分析。在实施集成样本转介系统之后，病毒载量覆盖率每月持续增加(p<0.001)，早期婴儿诊断周转时间提高了47.7％，样品量增加了25%。该研究确定了各种因素与测试结果之间的关联。这些发现表明病毒载量覆盖率和早期婴儿诊断周转时间的改善，并建议针对可修改的因素进一步优化转诊系统。我们建议继续加强转介系统，并更加审慎地制定创造需求的实施战略。
