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Abstract：
The role of inflammation in the pathophysiology of acute myocardial infarction (AMI) is well established. In recognizing inflammation\'s pivotal role in AMI, this manuscript systematically traces the historical studies spanning from early attempts to the present landscape. Several anti-inflammatory trials targeting inflammation in post-AMI have been performed, and this review includes the key trials, as well as examines their designs, patient demographics, and primary outcomes. Efficacies and challenges are analyzed, thereby shedding light on the translational implications of trial outcomes. This article also discusses emerging trends, ongoing research, and potential future directions in the field. Practical applications and implications for clinical practice are considered by providing a holistic view of the evolving landscape of anti-inflammatory interventions in the context of AMI.
摘要：
炎症在急性心肌梗死（AMI）的病理生理学中的作用已得到充分确立。在认识到炎症在AMI中的关键作用时，本手稿系统地追溯了从早期尝试到现在景观的历史研究。已经进行了几项针对AMI后炎症的抗炎试验，这次审查包括关键的试验，以及检查他们的设计，患者人口统计学，和主要结果。效率和挑战进行了分析，从而揭示了试验结果的翻译含义。本文还讨论了新兴趋势，正在进行的研究,以及该领域未来的潜在方向。通过提供AMI背景下抗炎干预措施不断发展的整体观点，考虑了实际应用和对临床实践的影响。
