PDF(Pubmed)
Abstract：
Diabetes is a chronic metabolic condition associated with high levels of blood glucose which leads to serious damage to the heart, kidney, eyes, and nerves. Elevated blood glucose levels damage brain function and cognitive abilities. They also lead to various neurological and neuropsychiatric disorders, including chronic neurodegeneration and cognitive decline. High neuronal glucose levels can cause drastic neuronal damage due to glucose neurotoxicity. Astrocytes, a type of glial cell, play a vital role in maintaining brain glucose levels through neuron-astrocyte coupling. Hyperglycemia leads to progressive decline in neuronal networks and cognitive impairment, contributing to neuronal dysfunction and fostering a neurodegenerative environment. In this review, we summarize the various connections, functions, and impairments of glial cells due to metabolic dysfunction in the diabetic brain. We also summarize the effects of hyperglycemia on various neuronal functions in the diabetic brain.
摘要：
糖尿病是一种慢性代谢疾病，与高水平的血糖相关，导致严重的心脏损害，肾,眼睛,和神经。血糖水平升高会损害脑功能和认知能力。它们还会导致各种神经和神经精神疾病，包括慢性神经变性和认知能力下降。高神经元葡萄糖水平可由于葡萄糖神经毒性而引起剧烈的神经元损伤。星形胶质细胞,一种神经胶质细胞,通过神经元-星形胶质细胞偶联在维持脑葡萄糖水平中起着至关重要的作用。高血糖导致神经元网络和认知障碍的进行性下降，有助于神经元功能障碍和促进神经退行性环境。在这次审查中,我们总结了各种联系，功能,和神经胶质细胞受损由于代谢功能障碍在糖尿病的大脑。我们还总结了高血糖对糖尿病脑中各种神经元功能的影响。
