PDF(Pubmed)
Abstract：
The prevalence of metabolic-associated fatty liver disease (MAFLD) is increasing globally due to factors such as urbanization, obesity, poor nutrition, sedentary lifestyles, healthcare accessibility, diagnostic advancements, and genetic influences. Research on MAFLD and HCC risk factors, pathogenesis, and biomarkers has been conducted through a narrative review of relevant studies, with a focus on PubMed and Web of Science databases and exclusion criteria based on article availability and language. Steatosis marks the early stage of MASH advancement, commonly associated with factors of metabolic syndrome such as obesity and type 2 diabetes. Various mechanisms, including heightened lipolysis, hepatic lipogenesis, and consumption of high-calorie diets, contribute to the accumulation of lipids in the liver. Insulin resistance is pivotal in the development of steatosis, as it leads to the release of free fatty acids from adipose tissue. Natural compounds hold promise in regulating lipid metabolism and inflammation to combat these conditions. Liver fibrosis serves as a significant predictor of MASH progression and HCC development, underscoring the need to target fibrosis in treatment approaches. Risk factors for MASH-associated HCC encompass advanced liver fibrosis, older age, male gender, metabolic syndrome, genetic predispositions, and dietary habits, emphasizing the requirement for efficient surveillance and diagnostic measures. Considering these factors, it is important for further studies to determine the biochemical impact of these risk factors in order to establish targeted therapies that can prevent the development of HCC or reduce progression of MASH, indirectly decreasing the risk of HCC.
摘要：
由于城市化等因素，代谢相关脂肪性肝病（MAFLD）的患病率在全球范围内正在增加，肥胖，营养不良,久坐的生活方式，医疗保健可及性，诊断进步，和遗传影响。MAFLD和HCC危险因素的研究，发病机制，生物标志物是通过对相关研究的叙述性回顾进行的，重点关注PubMed和WebofScience数据库以及基于文章可用性和语言的排除标准。脂肪变性标志着MASH进步的早期阶段，通常与肥胖和2型糖尿病等代谢综合征因素相关。各种机制,包括高度的脂解,肝脂肪生成，和高热量饮食的消费，有助于脂质在肝脏中的积累。胰岛素抵抗是脂肪变性发展的关键,因为它导致脂肪组织中游离脂肪酸的释放。天然化合物在调节脂质代谢和炎症以对抗这些疾病方面具有希望。肝纤维化是MASH进展和HCC发展的重要预测因子，强调了在治疗方法中靶向纤维化的必要性。MASH相关HCC的危险因素包括晚期肝纤维化，年龄较大,男性,代谢综合征,遗传倾向，和饮食习惯，强调对有效监测和诊断措施的要求。考虑到这些因素,重要的是进一步的研究，以确定这些危险因素的生化影响，以建立靶向治疗，可以预防HCC的发展或减少MASH的进展，间接降低HCC的风险。
