PDF(Pubmed)
Abstract：
Osteofibrous dysplasia (OFD) is a rare, benign, self-limited bone disorder with a relatively low incidence, accounting for approximately 0.2% of all primary bone tumors. It was frequently found intra-cortical of the mid-shaft of the tibia. OFD can also occur in other skeletal regions, including the fibula, ulna, radius, femur, humerus, ischium, rib, tarsus, metatarsals, vertebral, and capitate. OFD can present with asymptomatic, mass, pain, swelling, deformity, and even pathological fracture. OFD might be misdiagnosed as adamantinoma (AD) and because they are three subtypes origin from the same family of bone tumors and have similar imaging features. Moreover, pathology could provide evidence for an accurate diagnosis of OFD, but misdiagnosis may occur due to small sampling materials. To date, few studies have comprehensively introduced the epidemiology, clinical manifestations, pathogenesis, radiological features, pathology, and treatment for OFD. We herein discuss clinical signs, diagnosis methods, and treatment options of OFD to improve the understanding of OFD, which is helpful for accurate diagnosis and appropriate treatment.
摘要：
骨纤维发育不良（OFD）是一种罕见的，良性,自限性骨病发病率相对较低，约占所有原发性骨肿瘤的0.2％。经常在胫骨中轴的皮质内发现。OFD也可以发生在其他骨骼区域，包括腓骨,尺骨,半径,股骨,肱骨,坐骨,肋骨,tarsus,meta骨，椎骨,和头饰。OFD可以表现为无症状，质量,疼痛,肿胀,畸形,甚至是病理性骨折.OFD可能被误诊为金刚烷瘤（AD），因为它们是来自同一骨肿瘤家族的三种亚型，并且具有相似的影像学特征。此外，病理学可以为OFD的准确诊断提供证据，但由于取样材料少，可能会出现误诊。迄今为止,很少有研究全面介绍流行病学，临床表现，发病机制，放射学特征，病理学,和OFD的治疗。我们在这里讨论临床症状，诊断方法,以及OFD的治疗方案，以提高对OFD的理解，这有助于准确诊断和适当治疗。
