PDF(Pubmed)
Abstract：
BACKGROUND: Shoulder disorders, particularly rotator cuff tears, are prevalent musculoskeletal conditions related to aging. Although the widely used suture anchor technique provides strong mechanical support to the tendon, it is associated with a risk of postoperative tendon retearing. The conventionally used titanium alloys can affect the interpretation of magnetic resonance imaging. Degradable magnesium alloys possess excellent biocompatibility, similar mechanical property to the bone, and stimulating bone formation ability from Mg2+. The purpose of this experiment was to develop innovative magnesium-based suture anchors to enhance rotator cuff repair by improving fixation materials, and to evaluate their feasibility in a goat model.
METHODS: We developed fluoridized ZK60 suture anchors as the implantation material for two goats, who underwent rotator cuff repair surgery on both shoulders. Computed tomography (CT) and histological analysis were performed at 12 weeks postoperatively, and the results were compared between the magnesium and titanium alloy groups. Additionally, a hematological examination was conducted, which included assessments of red blood cells, white blood cells, platelets, coagulation function, liver function, kidney function, and magnesium ion concentration.
RESULTS: The 12-week postoperative CT images showed intact MgF2 ZK60 suture anchors, effectively reconnecting the infraspinatus tendon to the humeral head. The anchors became less visible on CT scans, indicating absorption by surrounding tissues. New bone formation in the MgF2 group surpassed that in the Ti group, demonstrating superior osseointegration. The similarity between cortical bone and magnesium reduced stress-shielding and promoted bone regeneration. Histological analysis revealed successful tendon healing with MgF2 anchors, while the Ti group showed discontinuous interfaces and reduced collagen secretion. Hematological examination showed stable liver, renal function, and magnesium ion levels.
CONCLUSIONS: The findings indicate that MgF2-coated suture anchors are feasible for rotator cuff repair and potentially other orthopedic applications. We hope that magnesium alloy anchors can become the solution for rotator cuff tendon repair surgery.
METHODS: We developed fluoridized ZK60 suture anchors as the implantation material for two goats, who underwent rotator cuff repair surgery on both shoulders. Computed tomography (CT) and histological analysis were performed at 12 weeks postoperatively, and the results were compared between the magnesium and titanium alloy groups. Additionally, a hematological examination was conducted, which included assessments of red blood cells, white blood cells, platelets, coagulation function, liver function, kidney function, and magnesium ion concentration.
RESULTS: The 12-week postoperative CT images showed intact MgF2 ZK60 suture anchors, effectively reconnecting the infraspinatus tendon to the humeral head. The anchors became less visible on CT scans, indicating absorption by surrounding tissues. New bone formation in the MgF2 group surpassed that in the Ti group, demonstrating superior osseointegration. The similarity between cortical bone and magnesium reduced stress-shielding and promoted bone regeneration. Histological analysis revealed successful tendon healing with MgF2 anchors, while the Ti group showed discontinuous interfaces and reduced collagen secretion. Hematological examination showed stable liver, renal function, and magnesium ion levels.
CONCLUSIONS: The findings indicate that MgF2-coated suture anchors are feasible for rotator cuff repair and potentially other orthopedic applications. We hope that magnesium alloy anchors can become the solution for rotator cuff tendon repair surgery.
摘要：
背景：肩部疾病，特别是肩袖撕裂，是与衰老有关的普遍肌肉骨骼疾病。尽管广泛使用的缝合锚钉技术为肌腱提供了强大的机械支撑，它与术后肌腱再脱的风险有关.常规使用的钛合金会影响磁共振成像的解释。可降解镁合金具有优异的生物相容性,与骨骼相似的机械性能，并刺激Mg2+的骨形成能力。本实验的目的是开发创新的镁基缝合锚钉，通过改进固定材料来增强肩袖修复，并评估其在山羊模型中的可行性。
方法：我们开发了氟化ZK60缝合锚钉作为两只山羊的植入材料，双肩肩袖修复手术.术后12周进行计算机断层扫描（CT）和组织学分析，并将结果在镁和钛合金组之间进行了比较。此外,进行了血液学检查，其中包括红细胞的评估，白细胞,血小板,凝血功能，肝功能,肾功能,和镁离子浓度。
结果：术后12周的CT图像显示完整的MgF2ZK60缝合锚钉，有效地将冈下肌腱重新连接到肱骨头。锚在CT扫描中变得不那么明显，指示周围组织的吸收。MgF2组的新骨形成超过Ti组，表现出优越的骨整合。皮质骨和镁之间的相似性降低了应力屏蔽并促进了骨再生。组织学分析显示，MgF2锚成功愈合肌腱，而Ti组显示界面不连续，胶原蛋白分泌减少。血液学检查显示肝脏稳定，肾功能,和镁离子水平。
结论：研究结果表明，MgF2涂层缝合锚钉可用于肩袖修复和潜在的其他骨科应用。我们希望镁合金锚钉能够成为肩袖肌腱修复手术的解决方案。
方法：我们开发了氟化ZK60缝合锚钉作为两只山羊的植入材料，双肩肩袖修复手术.术后12周进行计算机断层扫描（CT）和组织学分析，并将结果在镁和钛合金组之间进行了比较。此外,进行了血液学检查，其中包括红细胞的评估，白细胞,血小板,凝血功能，肝功能,肾功能,和镁离子浓度。
结果：术后12周的CT图像显示完整的MgF2ZK60缝合锚钉，有效地将冈下肌腱重新连接到肱骨头。锚在CT扫描中变得不那么明显，指示周围组织的吸收。MgF2组的新骨形成超过Ti组，表现出优越的骨整合。皮质骨和镁之间的相似性降低了应力屏蔽并促进了骨再生。组织学分析显示，MgF2锚成功愈合肌腱，而Ti组显示界面不连续，胶原蛋白分泌减少。血液学检查显示肝脏稳定，肾功能,和镁离子水平。
结论：研究结果表明，MgF2涂层缝合锚钉可用于肩袖修复和潜在的其他骨科应用。我们希望镁合金锚钉能够成为肩袖肌腱修复手术的解决方案。
