METHODS: In our current research, we employed comparative genomic techniques to demonstrate a correlation between the absence of gene expression due to a lack of CGIs in the gene promoters and pseudogenization.
RESULTS: We showed that there is a significant enrichment of tissue-specific genes in the functional orthologs of pseudogenes. We also found a significant correlation between the lack of CGIs and enriched tissue specificity in these functional orthologs of pseudogenes.
CONCLUSIONS: We inferred that perhaps tissue-specific genes are more prone to the process of pseudogenization. In this way, because of their impact on gene expression, CGIs may affect the fate of a gene. To our knowledge, this is the first study to propose a connection between CGIs, gene expression, and the pseudogenization process and discuss the evolutionary implications of this potential trilogy.
方法:在我们目前的研究中,我们采用比较基因组技术来证明由于基因启动子中缺乏CGI而导致的基因表达缺失与假基因化之间存在相关性.
结果:我们表明,在假基因的功能直系同源物中存在明显的组织特异性基因富集。我们还发现,在假基因的这些功能直系同源物中,CGI的缺乏与丰富的组织特异性之间存在显着相关性。
结论:我们推断可能组织特异性基因更倾向于假基因化过程。这样,因为它们对基因表达的影响,CGI可能影响基因的命运。据我们所知,这是第一个提出CGIs之间联系的研究,基因表达,和伪过程,并讨论这一潜在三部曲的进化意义。