Abstract：
BACKGROUND: Due to the heterogeneity of sarcoidosis, there is a need to define clinical phenotypes to allow for tailoring of clinical care and identification of more homogenous populations to facilitate research.
METHODS: We utilized data from a prospectively collected registry of sarcoidosis patients seen at a single quaternary referral center between January 2019 and February 2021. We used multiple correspondence analysis (MCA) and k-means clustering to investigate if the clusters previously identified in the GenPhenReSa study were reproducible in a US population. We also investigated if these clusters were stable when the population was stratified by race.
RESULTS: We replicated 3 of the 5 clusters seen in the GenPhenReSa study in our cohort. We likewise identified similar clusters between White and Black patients with sarcoidosis. Differences in organ manifestations associations between White and Black patients were seen primarily in relation to cardiac, neurologic, and ocular involvement.
CONCLUSIONS: The organ clusters of liver-spleen, isolated pulmonary, and musculoskeletal-skin were reproducible in a US cohort, and in both Black and White patients.
METHODS: We utilized data from a prospectively collected registry of sarcoidosis patients seen at a single quaternary referral center between January 2019 and February 2021. We used multiple correspondence analysis (MCA) and k-means clustering to investigate if the clusters previously identified in the GenPhenReSa study were reproducible in a US population. We also investigated if these clusters were stable when the population was stratified by race.
RESULTS: We replicated 3 of the 5 clusters seen in the GenPhenReSa study in our cohort. We likewise identified similar clusters between White and Black patients with sarcoidosis. Differences in organ manifestations associations between White and Black patients were seen primarily in relation to cardiac, neurologic, and ocular involvement.
CONCLUSIONS: The organ clusters of liver-spleen, isolated pulmonary, and musculoskeletal-skin were reproducible in a US cohort, and in both Black and White patients.
摘要：
背景：由于结节病的异质性，有必要定义临床表型，以适应临床护理和识别更同质的人群，以促进研究。
方法：我们利用了2019年1月至2021年2月在一个四元转诊中心前瞻性收集的结节病患者登记数据。我们使用多重对应分析（MCA）和k均值聚类来调查先前在GenPhenReSa研究中确定的聚类在美国人群中是否可重复。我们还调查了当人口按种族分层时，这些集群是否稳定。
结果：我们在我们的队列中复制了GenPhenReSa研究中看到的5个集群中的3个。我们同样确定了白色和黑色结节病患者之间的相似簇。白人和黑人患者之间的器官表现关联差异主要与心脏有关，神经学，和眼部受累。
结论：肝脾器官簇，孤立的肺，肌肉骨骼皮肤在美国队列中是可重复的，黑人和白人患者。
方法：我们利用了2019年1月至2021年2月在一个四元转诊中心前瞻性收集的结节病患者登记数据。我们使用多重对应分析（MCA）和k均值聚类来调查先前在GenPhenReSa研究中确定的聚类在美国人群中是否可重复。我们还调查了当人口按种族分层时，这些集群是否稳定。
结果：我们在我们的队列中复制了GenPhenReSa研究中看到的5个集群中的3个。我们同样确定了白色和黑色结节病患者之间的相似簇。白人和黑人患者之间的器官表现关联差异主要与心脏有关，神经学，和眼部受累。
结论：肝脾器官簇，孤立的肺，肌肉骨骼皮肤在美国队列中是可重复的，黑人和白人患者。
