Abstract：
BACKGROUND: Pulmonary arterial hypertension (PAH) is a fatal disease caused by pulmonary vascular remodeling, with a high incidence and mortality. At present, many clinical drugs for treating PAH mainly exert effects by relaxing the pulmonary artery, with limited therapeutic effects, so the search for viable therapeutic agents continues uninterrupted. In recent years, natural flavonoids have shown promising potential in the treatment of cardiovascular diseases. It is necessary to comprehensively elucidate the potential of natural flavonoids to combat PAH.
OBJECTIVE: To evaluate the potential of natural flavonoids to hinder or slow down the occurrence and development of PAH, and to identify promising drug discovery candidates.
METHODS: Literature was collected from PubMed, Science Direct, Web of science, CNKI databases and Google scholar. The search terms used included \"pulmonary arterial hypertension\", \"pulmonary hypertension\", \"natural products\", \"natural flavonoids\", \"traditional chinese medicine\", etc., and several combinations of these keywords.
RESULTS: The resources, structural characteristics, mechanisms, potential and prospect strategies of natural flavonoids for treating PAH were summarized. Natural flavonoids offer different solutions as possible treatments for PAH. These mechanisms may involve various pathways and molecular targets related to the pathogenesis of PAH, such as inflammation, oxidative stress, vascular remodeling, genetic, ion channels, cell proliferation and autophagy. In addition, prospect strategies of natural flavonoids for anti-PAH including structural modification and nanomaterial delivery systems have been explored. This review suggests that the potential of natural flavonoids as alternative therapeutic agents in the prevention and treatment of PAH holds promise for future research and clinical applications.
CONCLUSIONS: Despite displaying the enormous potential of flavonoids in PAH, some limitations need to be further explored. Firstly, using advanced drug discovery tools, including computer-aided design and high-throughput screening, to further investigate the safety, biological activity, and precise mechanism of action of flavonoids. Secondly, exploring the structural modifications of these compounds is expected to optimize their efficacy. Lastly, it is necessary to conduct well controlled clinical trials and a comprehensive evaluation of potential side effects to determine their effectiveness and safety.
OBJECTIVE: To evaluate the potential of natural flavonoids to hinder or slow down the occurrence and development of PAH, and to identify promising drug discovery candidates.
METHODS: Literature was collected from PubMed, Science Direct, Web of science, CNKI databases and Google scholar. The search terms used included \"pulmonary arterial hypertension\", \"pulmonary hypertension\", \"natural products\", \"natural flavonoids\", \"traditional chinese medicine\", etc., and several combinations of these keywords.
RESULTS: The resources, structural characteristics, mechanisms, potential and prospect strategies of natural flavonoids for treating PAH were summarized. Natural flavonoids offer different solutions as possible treatments for PAH. These mechanisms may involve various pathways and molecular targets related to the pathogenesis of PAH, such as inflammation, oxidative stress, vascular remodeling, genetic, ion channels, cell proliferation and autophagy. In addition, prospect strategies of natural flavonoids for anti-PAH including structural modification and nanomaterial delivery systems have been explored. This review suggests that the potential of natural flavonoids as alternative therapeutic agents in the prevention and treatment of PAH holds promise for future research and clinical applications.
CONCLUSIONS: Despite displaying the enormous potential of flavonoids in PAH, some limitations need to be further explored. Firstly, using advanced drug discovery tools, including computer-aided design and high-throughput screening, to further investigate the safety, biological activity, and precise mechanism of action of flavonoids. Secondly, exploring the structural modifications of these compounds is expected to optimize their efficacy. Lastly, it is necessary to conduct well controlled clinical trials and a comprehensive evaluation of potential side effects to determine their effectiveness and safety.
摘要：
背景：肺动脉高压（PAH）是由肺血管重塑引起的致命疾病，发病率和死亡率高。目前,许多临床治疗PAH的药物主要通过舒张肺动脉来发挥作用,治疗效果有限，因此，寻找可行的治疗药物仍在不间断地继续。近年来,天然黄酮类化合物在治疗心血管疾病方面显示出有希望的潜力。有必要全面阐明天然黄酮类化合物对抗PAH的潜力。
目的：评估天然黄酮类化合物阻碍或减缓PAH发生和发展的潜力，并确定有希望的候选药物。
方法：文献来自PubMed，科学直接，WebofScience,CNKI数据库和谷歌学者使用的搜索词包括“肺动脉高压”，“肺动脉高压”，“天然产物”，“天然类黄酮”，“中医”，等。,以及这些关键字的几种组合。
结果：资源，结构特征，机制,总结了天然黄酮类化合物治疗多环芳烃的潜力和前景。天然类黄酮提供不同的解决方案作为可能的治疗PAH。这些机制可能涉及与PAH发病相关的多种通路和分子靶点,比如炎症，氧化应激，血管重塑,遗传,离子通道,细胞增殖和自噬。此外,已经探索了天然类黄酮用于抗PAH的前景策略，包括结构修饰和纳米材料递送系统。这篇综述表明，天然类黄酮作为预防和治疗PAH的替代治疗剂的潜力为未来的研究和临床应用提供了希望。
结论：尽管类黄酮在PAH中显示出巨大的潜力，一些限制需要进一步探索。首先,使用先进的药物发现工具，包括计算机辅助设计和高通量筛选，为了进一步调查安全性，生物活性,以及黄酮类化合物的精确作用机制。其次,探索这些化合物的结构修饰有望优化其功效。最后,有必要进行良好的对照临床试验和对潜在副作用的综合评估，以确定其有效性和安全性。
目的：评估天然黄酮类化合物阻碍或减缓PAH发生和发展的潜力，并确定有希望的候选药物。
方法：文献来自PubMed，科学直接，WebofScience,CNKI数据库和谷歌学者使用的搜索词包括“肺动脉高压”，“肺动脉高压”，“天然产物”，“天然类黄酮”，“中医”，等。,以及这些关键字的几种组合。
结果：资源，结构特征，机制,总结了天然黄酮类化合物治疗多环芳烃的潜力和前景。天然类黄酮提供不同的解决方案作为可能的治疗PAH。这些机制可能涉及与PAH发病相关的多种通路和分子靶点,比如炎症，氧化应激，血管重塑,遗传,离子通道,细胞增殖和自噬。此外,已经探索了天然类黄酮用于抗PAH的前景策略，包括结构修饰和纳米材料递送系统。这篇综述表明，天然类黄酮作为预防和治疗PAH的替代治疗剂的潜力为未来的研究和临床应用提供了希望。
结论：尽管类黄酮在PAH中显示出巨大的潜力，一些限制需要进一步探索。首先,使用先进的药物发现工具，包括计算机辅助设计和高通量筛选，为了进一步调查安全性，生物活性,以及黄酮类化合物的精确作用机制。其次,探索这些化合物的结构修饰有望优化其功效。最后,有必要进行良好的对照临床试验和对潜在副作用的综合评估，以确定其有效性和安全性。
