PDF(Pubmed)
Abstract：
An important cellular barrier to maintain the stability of the brain\'s internal and external environment is the blood-brain barrier (BBB). It also prevents harmful substances from entering brain tissue through blood circulation while providing protection for the central nervous system. It should be noted, however, that the intact BBB can be a barrier to the transport of most drugs into the brain via the conventional route of administration, which can prevent them from reaching effective concentrations for the treatment of disorders affecting the central nervous system. Electroacupuncture stimulation has been shown to be effective at opening the BBB in a series of experimental studies. This study systematically analyzes the possibility and mechanism by which electroacupuncture opens the BBB. In PubMed, Web of Science, VIP Database, Wanfang Database, and the Chinese National Knowledge Infrastructure, papers have been published for nearly 22 years aimed at opening the BBB and its associated structures. A comparison of EB content between electroacupuncture and control was selected as the primary outcome. There were also results on vascular endothelial growth factor (VEGF), nerve growth factor (NGF), P-Glycoprotein (P-gp), Matrix Metalloproteinase 9 (MMP-9), and glial fibrillary acidic protein (GFAP). We utilized Review Manager software analysis to analyze correlations between studies with a view to exploring the mechanisms of similarity. Evans Blue infiltration forest plot: pooled effect size of 2.04, 95% CI: 1.21 to 2.87, P < 0.01. These results indicate that electroacupuncture significantly increases EB penetration across the BBB. Most studies have reported that GFAP, MMP-9, and VEGF were upregulated after treatment. P-gp expression decreased as well. Electroacupuncture can open the BBB, and the sparse-dense wave is currently the most effective electroacupuncture frequency for opening the BBB. VEGF plays an important role in opening the BBB. It is also important to regulate the expression of MMP-9 and GFAP and inhibit the expression of P-gp.
摘要：
血脑屏障(BBB)是维持大脑内外环境稳定的重要细胞屏障。它还可以防止有害物质通过血液循环进入脑组织，同时为中枢神经系统提供保护。应该注意,然而,完整的血脑屏障可能是大多数药物通过常规给药途径转运到大脑中的障碍，这可以防止它们达到治疗影响中枢神经系统的疾病的有效浓度。在一系列实验研究中，电针刺激已被证明可有效打开BBB。本研究系统分析了电针打开血脑屏障的可能性和机制。在PubMed中,WebofScience,VIP数据库,万方数据库,和中国国家知识基础设施，论文已经发表了近22年，旨在打开BBB及其相关结构。选择电针和对照之间EB含量的比较作为主要结果。血管内皮生长因子（VEGF）也有结果，神经生长因子(NGF),P-糖蛋白(P-gp),基质金属蛋白酶9(MMP-9),和胶质纤维酸性蛋白（GFAP）。我们利用ReviewManager软件分析来分析研究之间的相关性，以期探索相似性的机制。伊文思蓝渗入林地块:合并效应大小为2.04,95%CI:1.21~2.87,P<0.01。这些结果表明，电针显着增加了EB在BBB中的渗透。大多数研究报道GFAP，治疗后MMP-9和VEGF上调。P-gp表达也降低。电针可以打开血脑屏障，疏密波是目前最有效的打开血脑屏障的电针频率。VEGF在开辟BBB中起主要感化。调节MMP-9和GFAP的表达以及抑制P-gp的表达也很重要。
