Abstract：
UNASSIGNED: Mixed connective tissue disease (MCTD) is a systemic autoimmune disease with features overlapping multiple autoimmune disorders. One study found that over 55% of patients with MCTD experienced neuropsychiatric symptoms, the most common of which was an \"aseptic meningitis-like syndrome.\" We present a case of a 17-year-old adolescent girl presenting with abnormal speech and behavior, auditory hallucinations, and paranoid delusions after an isolated episode of fever. She was treated for her psychotic symptoms but later developed symptoms resembling neuroleptic malignant syndrome. An antibody screen revealed elevated anti-U1-ribonucleoprotein antibodies with a possible diagnosis of MCTD. She finally responded to steroid therapy. To our knowledge, this is the first reported case of MCTD initially presenting with psychosis. A diagnosis of autoimmune disorders should be kept in the differential of similar clinical presentations including connective tissue disorders and autoimmune thyroid conditions.
摘要：
混合性结缔组织病（MCTD）是一种全身性自身免疫性疾病，其特征与多种自身免疫性疾病重叠。一项研究发现，超过55%的MCTD患者出现神经精神症状，其中最常见的是无菌性脑膜炎样综合征。“我们提出了一个案例，一个17岁的青春期女孩表现出异常的言语和行为，幻听,和孤立的发烧后的妄想症。她因精神病症状接受了治疗，但后来出现了类似精神阻滞剂恶性综合征的症状。抗体筛查显示抗U1-核糖核蛋白抗体升高，可能诊断为MCTD。她终于对类固醇疗法有了反应。据我们所知,这是报道的首例最初表现为精神病的MCTD病例.自身免疫性疾病的诊断应保持在类似临床表现的差异中，包括结缔组织疾病和自身免疫性甲状腺疾病。
