PDF(Pubmed)
Abstract：
Recent events concerning jet fuel contamination of drinking water have shown that we need a better understanding of the effects of ingested jet fuel. To this end, a reproductive study with ingested jet fuel in rats was undertaken with relatively high concentrations of Jet Propellant (JP)-5 along with a human estrogen receptor activation in vitro assay using JP-5, JP-8, and an alternative jet fuel derived from the camelina plant referred to as HydroRenewable Jet (HRJ) fuel, to help evaluate potential effects of ingested jet fuel. The results of the in vivo study provide evidence that JP-5 can act as an endocrine disruptor, with specific observations including altered hormone levels with JP-5 exposure (significantly lower estradiol levels in male rats and significantly increased Dehydroepiandrosterone levels in females), and a decreased male/female offspring ratio. The in vitro hormone receptor activation assay indicated that JP-5 and JP-8 are capable of upregulating human estrogen receptor (ER) activity, while HRJ was not active in the ER assay. The jet fuels were not able to activate androgen or glucocorticoid receptors in further in vitro assays. These results infer potential endocrine disruption associated with JP-5, with activation of the estrogen receptor as one potential mechanism of action.
摘要：
有关饮用水喷气燃料污染的最新事件表明，我们需要更好地了解摄入喷气燃料的影响。为此,使用相对高浓度的喷射推进剂（JP）-5以及使用JP-5，JP-8进行的人雌激素受体激活体外测定以及从骆驼植物中获得的替代喷射燃料进行的生殖研究被称为HydroRenewableJet（HRJ）燃料，以帮助评估摄入喷气燃料的潜在影响。体内研究的结果提供了JP-5可以作为内分泌干扰物的证据，具体观察包括JP-5暴露后激素水平改变（雄性大鼠雌二醇水平显着降低，雌性大鼠脱氢表雄酮水平显着升高），和下降的男性/女性后代比例。体外激素受体激活试验表明，JP-5和JP-8能够上调人雌激素受体（ER）活性，而HRJ在ER测定中没有活性。在进一步的体外测定中，喷气燃料无法激活雄激素或糖皮质激素受体。这些结果推断了与JP-5相关的潜在内分泌干扰，雌激素受体的激活是一种潜在的作用机制。
