PDF(Pubmed)
Abstract：
Aim: Angioid streaks (ASs) are a rare retinal condition and compromise visual acuity when complicated with choroidal neovascularization (CNV). They represent crack-like dehiscences at the level of the Bruch\'s membrane. This objective narrative review aims to provide an overview of pathophysiology, current treatment modalities, and future perspectives on this condition. Materials and Methods: A literature search was performed using \"PubMed\", \"Web of Science\", \"Scopus\", \"ScienceDirect\", \"Google Scholar\", \"medRxiv\", and \"bioRxiv.\" Results: ASs may be idiopathic, but they are also associated with systemic conditions, such as pseudoxanthoma elasticum, hereditary hemoglobinopathies, or Paget\'s disease. Currently, the main treatment is the use of anti-vascular endothelial growth factors (anti-VEGF) to treat secondary CNV, which is the major complication observed in this condition. If CNV is detected and treated promptly, patients with ASs have a good chance of maintaining functional vision. Other treatment modalities have been tried but have shown limited benefit and, therefore, have not managed to be more widely accepted. Conclusion: In summary, although there is no definitive cure yet, the use of anti-VEGF treatment for secondary CNV has provided the opportunity to maintain functional vision in individuals with AS, provided that CNV is detected and treated early.
摘要：
目的：血管样条纹（AS）是一种罕见的视网膜疾病，当并发脉络膜新生血管（CNV）时，视力受损。它们代表布鲁赫膜水平的裂纹状开裂。这篇客观的叙事综述旨在提供病理生理学的概述，目前的治疗方式，以及在这种情况下的未来前景。材料与方法：使用“PubMed”进行文献检索，\"WebofScience\",\"Scopus\",“科学直接”，“谷歌学者”，\"medRxiv\",和“bioRxiv。“结果：AS可能是特发性的，但它们也与系统条件有关，比如弹性假性黄瘤，遗传性血红蛋白病,或者Paget的病.目前,主要治疗方法是使用抗血管内皮生长因子（anti-VEGF）治疗继发性CNV，这是在这种情况下观察到的主要并发症。如果CNV被及时检测和治疗，ASs患者有很好的机会维持功能性视力。其他治疗方式已经尝试，但显示出有限的益处，因此,没有被更广泛地接受。结论：总之，虽然目前还没有明确的治疗方法,抗VEGF治疗继发性CNV为维持AS患者的功能性视力提供了机会,前提是早期检测和治疗CNV。
