PDF(Pubmed)
Abstract：
Changes in lighting accompany modern urbanization trends and can lead to various pathologies based on circadian disturbances. In this study, we assessed the changes in the circadian rhythm of core body temperature (Tcore) and locomotor activity of Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR) following exposure to different lighting conditions: extended light phase of the day (16 h-8 h, 20 h-4 h, 24 h-0 h), light pollution, monochromatic light, and bright light therapy. The telemetry data was collected after experimental lighting conditions during periods with standard lighting (12 h of light and 12 h of darkness) and was processed using linear and cosinor analysis. The daily rhythms of rats\' parameters persisted in accordance with the standard lighting regime. Tcore changes were observed in both groups compared to the initial period: in WKY, a decrease in Tcore during the darkness and an increase during the light; in SHR, the opposite trend, with Tcore increased during the darkness and decreased during the light phase of the day. A relationship between Tcore and activity was observed with weak correlation. WKY exhibited more pronounced signs of adaptive variation and desynchronization compared to SHR, which could be associated with a wider range of functional capabilities of the organism without cardiovascular pathology.
摘要：
照明的变化伴随着现代城市化趋势，并可能导致基于昼夜节律干扰的各种病理。在这项研究中,我们评估了暴露于不同光照条件后，Wistar-Kyoto大鼠（WKY）和自发性高血压大鼠（SHR）的核心体温昼夜节律（16h-8h，20h-4h,24h-0h)，光污染,单色光,和明亮的光疗法。在具有标准照明（12小时的光照和12小时的黑暗）期间的实验照明条件下收集遥测数据，并使用线性和余弦分析进行处理。大鼠的每日节律参数保持与标准照明制度一致。与初始阶段相比，两组均观察到了T值变化：在WKY，在黑暗中，分数减少，在光照中增加；在SHR中，相反的趋势，Tcore在黑暗中增加，在白天的光照阶段减少。观察到Tcore与活性之间的关系具有弱相关性。与SHR相比，WKY表现出更明显的适应性变异和去同步迹象，这可能与生物体的更广泛的功能能力有关，而没有心血管病理学。
