PDF(Pubmed)
Abstract：
Two new sesquiterpenoid derivatives, elgonenes M (1) and N (2), and a new shikimic acid metabolite, methyl 5-O-acetyl-5-epi-shikimate (3), were isolated from the mangrove sediment-derived fungus Roussoella sp. SCSIO 41427 together with fourteen known compounds (4-17). The planar structures were elucidated through nuclear magnetic resonance (NMR) and mass spectroscopic (MS) analyses. The relative configurations of 1-3 were ascertained by NOESY experiments, while their absolute configurations were determined by electronic circular dichroism (ECD) calculation. Elgonene M (1) exhibited inhibition of interleukin-1β (IL-1β) mRNA, a pro-inflammatory cytokine, at a concentration of 5 μM, with an inhibitory ratio of 31.14%. On the other hand, elgonene N (2) demonstrated inhibition at a concentration of 20 μM, with inhibitory ratios of 27.57%.
摘要：
两种新的倍半萜衍生物，萜烯M(1)和N(2)，和一种新的莽草酸代谢产物，5-O-乙酰基-5-表-莽草酸甲酯（3），从红树林沉积物衍生的真菌Roussoellasp.中分离出来。SCSIO41427与14种已知化合物(4-17)一起使用。通过核磁共振(NMR)和质谱(MS)分析阐明平面结构。1-3的相对构型通过NOESY实验确定，而它们的绝对构型是通过电子圆二色性（ECD）计算确定的。ElgoneneM（1）显示抑制白细胞介素-1β（IL-1β）mRNA，一种促炎细胞因子，浓度为5μM，抑制率为31.14%。另一方面,在20μM的浓度下显示出的地衣烯N（2）具有抑制作用，抑制率为27.57%。
