PDF(Pubmed)
Abstract：
IL-15 is a proinflammatory myokine essential for activating NK cells and CD8+ T lymphocytes, and its overexpression has been related to reducing overall survivorship in patients with acute lymphoblastic leukemia (ALL). Physical exercise has been shown to be safe, feasible, and beneficial in hematological cancers. Exercise requires the activation of muscles that secrete cytokines, such as IL-15, causing immune mobilization. The objective was to compare the outcomes of two training routines on IL-15 and survival prognosis in adult patients diagnosed with ALL. A blind randomized clinical study was carried out where twenty-three peripheral blood samples were obtained pre and postexercise intervention from patients categorized into three types of intervention: the resistance exercise group (REG), the cross-training exercise group (CEG), and the control group (CG). Changes in IL-15 levels during the intervention were not significant in any of the groups (CG p = 0.237, REG p = 0.866, and CEG p = 0.678). However, 87.5% of patients who received an exercise intervention achieved remission, while only 21.73% experienced a relapse. There were no deaths during the study. Although IL-15 level adaptation in the REG and the CG performed similarly, the REG induced a better clinical outcome. Resistance exercises may help improve survival prognosis and reduce relapses in patients with ALL.
摘要：
IL-15是激活NK细胞和CD8+T淋巴细胞所必需的促炎性肌动蛋白，其过度表达与降低急性淋巴细胞白血病（ALL）患者的总体生存率有关。体育锻炼已被证明是安全的，可行,对血液癌症有益。运动需要激活分泌细胞因子的肌肉，如IL-15，引起免疫动员。目的是比较诊断为ALL的成年患者的IL-15和生存预后的两种训练方法的结果。进行了一项盲随机临床研究，在运动干预前后从分为三种干预类型的患者中获取了23个外周血样本：抗阻运动组（REG），交叉训练组(CEG)，对照组（CG）。干预期间IL-15水平的变化在任何组中都不显著(CGp=0.237,REGp=0.866,CEGp=0.678)。然而,接受运动干预的患者中，87.5%的患者获得了缓解，而只有21.73%的人经历了复发。研究期间没有死亡。尽管REG和CG中的IL-15水平适应类似地执行，REG诱导了更好的临床结果。抗阻运动可能有助于改善ALL患者的生存预后并减少复发。
