PDF(Pubmed)
Abstract：
A vast range of pesticides have been routinely employed for plant protection throughout the last few decades. Pesticides can enter non-target organisms in various ways, posing health hazards. Exposure to different environmental pollutants, including pesticides, can affect the human gut flora. Metabolites generated from the gut microbiota play an essential role in the host\'s health by regulating metabolic homeostasis. A disruption in this equilibrium can lead to the emergence of numerous illnesses and their etiology. Pesticides have been shown in a few recent studies to harm the host\'s gut microbiome. As a result, there is an urgent need to investigate the impact of pesticides on gut microbiota-mediated immunity. Metabolic alterations in the host may give a better understanding of pesticide-induced harm. This review highlights the potential consequences of pesticide exposure on gut microbiota composition and function, mainly focusing on how it might alter the production of secondary metabolites with potential downstream implications for host health.
摘要：
在过去的几十年中,广泛的杀虫剂已经被常规地用于植物保护。农药可以通过多种途径进入非靶标生物,危害健康。暴露于不同的环境污染物，包括杀虫剂,会影响人体肠道菌群。肠道微生物产生的代谢产物通过调节代谢稳态在宿主的健康中起着至关重要的作用。这种平衡的破坏可能导致许多疾病及其病因的出现。最近的一些研究表明，农药会损害宿主的肠道微生物组。因此,迫切需要研究农药对肠道微生物群介导的免疫的影响。宿主的代谢改变可能会更好地了解农药引起的危害。这篇综述强调了农药暴露对肠道微生物群组成和功能的潜在影响。主要关注它如何改变次级代谢产物的产生，对宿主健康具有潜在的下游影响。
