PDF(Pubmed)
Abstract：
Immune-checkpoint inhibitors have profoundly changed cancer treatment, improving the prognosis of many oncologic patients. However, despite the good efficacy of these drugs, their mechanism of action, which involves the activation of the immune system, can lead to immune-related adverse events, which may affect almost all organs. Pulmonary adverse events are relatively common, and potentially life-threatening complications may occur. The diagnosis is challenging due to the wide and non-specific spectrum of clinical and radiological manifestations. The role of the radiologist is to recognize and diagnose pulmonary immune-related adverse events, possibly even in the early stages, to estimate their extent and guide patients\' management.
摘要：
免疫检查点抑制剂已经深刻地改变了癌症治疗，改善许多肿瘤患者的预后。然而,尽管这些药物有很好的疗效，他们的作用机制，涉及免疫系统的激活，可能导致免疫相关的不良事件，这可能会影响几乎所有的器官。肺部不良事件相对常见，和潜在的危及生命的并发症可能发生。由于临床和放射学表现的广谱和非特异性，诊断具有挑战性。放射科医生的作用是识别和诊断肺部免疫相关的不良事件，甚至可能在早期阶段，估计其程度并指导患者管理。
