PDF(Pubmed)
Abstract：
Transient receptor potential vanilloid-6 (TRPV6) is a cation channel belonging to the TRP superfamily, specifically the vanilloid subfamily, and is the sixth member of this subfamily. Its presence in the body is primarily limited to the skin, ovaries, kidney, testes, and digestive tract epithelium. The body maintains calcium homeostasis using the TRPV6 channel, which has a greater calcium selectivity than the other TRP channels. Several pieces of evidence suggest that it is upregulated in the advanced stages of thyroid, ovarian, breast, colon, and prostate cancers. The function of TRPV6 in regulating calcium signaling in cancer will be covered in this review, along with its potential applications as a cancer treatment target.
摘要：
瞬时受体电位香草素-6（TRPV6）是属于TRP超家族的阳离子通道，特别是香草素亚科，是这个亚家族的第六个成员.它在体内的存在主要限于皮肤，卵巢,肾,睾丸,和消化道上皮。身体使用TRPV6通道维持钙稳态，其具有比其他TRP通道更大的钙选择性。几项证据表明，它在甲状腺的晚期被上调，卵巢,乳房,结肠,和前列腺癌。本文将对TRPV6在癌症中调节钙信号的功能进行综述。以及它作为癌症治疗靶点的潜在应用。
