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Abstract：
This review discusses the relationship between cellular senescence and radiation exposure. Given the wide range of ionizing radiation sources encountered by people in professional and medical spheres, as well as the influence of natural background radiation, the question of the effect of radiation on biological processes, particularly on aging processes, remains highly relevant. The parallel relationship between natural and radiation-induced cellular senescence reveals the common aspects underlying these processes. Based on recent scientific data, the key points of the effects of ionizing radiation on cellular processes associated with aging, such as genome instability, mitochondrial dysfunction, altered expression of miRNAs, epigenetic profile, and manifestation of the senescence-associated secretory phenotype (SASP), are discussed. Unraveling the molecular mechanisms of cellular senescence can make a valuable contribution to the understanding of the molecular genetic basis of age-associated diseases in the context of environmental exposure.
摘要：
本文综述了细胞衰老与辐射暴露之间的关系。鉴于专业和医疗领域的人们遇到的电离辐射源范围广泛，以及自然背景辐射的影响，辐射对生物过程的影响，特别是在老化过程中，仍然高度相关。自然和辐射诱导的细胞衰老之间的平行关系揭示了这些过程的共同方面。根据最近的科学数据,电离辐射对衰老相关细胞过程影响的关键点，比如基因组不稳定，线粒体功能障碍，miRNA表达改变，表观遗传概况，和衰老相关分泌表型（SASP）的表现，正在讨论。解开细胞衰老的分子机制可以为在环境暴露的背景下理解年龄相关疾病的分子遗传基础做出有价值的贡献。
