PDF(Pubmed)
Abstract：
UNASSIGNED: Inflammation is crucial in the pathogenesis of chronic spontaneous urticaria (CSU). Investigating the correlation between levels of serum inflammatory cytokines (SICs) and the severity of CSU is of great significance for understanding the disease mechanism and finding effective treatment strategies.
UNASSIGNED: In this context, this work was developed.
UNASSIGNED: This work involved a researchy group (Res group) of 114 patients with CSU and a control group (Ctrl group) of 100 healthy individuals. SICs including leukotriene B4 (LTB4), leukotriene C4 (LTC4), interleukin (IL) 4 (IL-4), IL-17, IL-31, and tumor necrosis factor-γ (TNF-γ), of patients in different groups were measured and compared. Furthermore, the correlations between each SIC and pruritus severity, duration of pruritus, urticaria activity, and quality of life (QOL) were compared among the patients in different groups.
UNASSIGNED: The Res group exhibited higher levels of LTB4, LTC4, IL-4, IL-17, and IL-31 but lower levels of TNF-γ. Great differences (p < 0.05) were found in IL-4, IL-17, and IL-31 among the patients with different pruritus severity, and positive correlations were observed between IL-17 and IL-31 levels and urticaria activity in the patients (p < 0.05). Additionally, levels of IL-4 and IL-31 exhibited a positive association to QOL scores in the patients, with obvious differences (p < 0.05).
UNASSIGNED: IL-4, IL-17, and IL-31 showed the strongest correlation with the severity of CSU, which may be attributed to their involvement in immune, inflammatory, and pruritic reactions, exacerbating the disease condition.
UNASSIGNED: In this context, this work was developed.
UNASSIGNED: This work involved a researchy group (Res group) of 114 patients with CSU and a control group (Ctrl group) of 100 healthy individuals. SICs including leukotriene B4 (LTB4), leukotriene C4 (LTC4), interleukin (IL) 4 (IL-4), IL-17, IL-31, and tumor necrosis factor-γ (TNF-γ), of patients in different groups were measured and compared. Furthermore, the correlations between each SIC and pruritus severity, duration of pruritus, urticaria activity, and quality of life (QOL) were compared among the patients in different groups.
UNASSIGNED: The Res group exhibited higher levels of LTB4, LTC4, IL-4, IL-17, and IL-31 but lower levels of TNF-γ. Great differences (p < 0.05) were found in IL-4, IL-17, and IL-31 among the patients with different pruritus severity, and positive correlations were observed between IL-17 and IL-31 levels and urticaria activity in the patients (p < 0.05). Additionally, levels of IL-4 and IL-31 exhibited a positive association to QOL scores in the patients, with obvious differences (p < 0.05).
UNASSIGNED: IL-4, IL-17, and IL-31 showed the strongest correlation with the severity of CSU, which may be attributed to their involvement in immune, inflammatory, and pruritic reactions, exacerbating the disease condition.
摘要：
■炎症在慢性自发性荨麻疹（CSU）的发病机理中至关重要。研究血清炎症因子(SICs)水平与CSU病情严重程度的相关性,对于了解CSU的发病机制和寻找有效的治疗策略具有重要意义。
■在这种情况下，这项工作得到了发展。
■这项工作涉及114名CSU患者的研究组（Res组）和100名健康个体的对照组（Ctrl组）。SIC包括白三烯B4（LTB4），白三烯C4（LTC4），白细胞介素（IL）4（IL-4），IL-17，IL-31和肿瘤坏死因子-γ（TNF-γ），对不同组的患者进行测量和比较。此外，每个SIC和瘙痒严重程度之间的相关性，瘙痒的持续时间，荨麻疹活动，比较不同组患者的生活质量。
■Res组表现出更高水平的LTB4、LTC4、IL-4、IL-17和IL-31,但更低水平的TNF-γ。不同皮肤瘙痒程度患者的IL-4、IL-17、IL-31差异有统计学意义(p<0.05)。患者的IL-17和IL-31水平与荨麻疹活性呈正相关（p<0.05）。此外,IL-4和IL-31的水平与患者的QOL评分呈正相关，具有明显差异(p<0.05)。
■IL-4，IL-17和IL-31与CSU的严重程度相关性最强，这可能归因于他们参与免疫，炎症，和瘙痒反应，加重病情。
■在这种情况下，这项工作得到了发展。
■这项工作涉及114名CSU患者的研究组（Res组）和100名健康个体的对照组（Ctrl组）。SIC包括白三烯B4（LTB4），白三烯C4（LTC4），白细胞介素（IL）4（IL-4），IL-17，IL-31和肿瘤坏死因子-γ（TNF-γ），对不同组的患者进行测量和比较。此外，每个SIC和瘙痒严重程度之间的相关性，瘙痒的持续时间，荨麻疹活动，比较不同组患者的生活质量。
■Res组表现出更高水平的LTB4、LTC4、IL-4、IL-17和IL-31,但更低水平的TNF-γ。不同皮肤瘙痒程度患者的IL-4、IL-17、IL-31差异有统计学意义(p<0.05)。患者的IL-17和IL-31水平与荨麻疹活性呈正相关（p<0.05）。此外,IL-4和IL-31的水平与患者的QOL评分呈正相关，具有明显差异(p<0.05)。
■IL-4，IL-17和IL-31与CSU的严重程度相关性最强，这可能归因于他们参与免疫，炎症，和瘙痒反应，加重病情。
