PDF(Pubmed)
Abstract：
Cryptorchidism is the condition in which one or both testes have not descended adequately into the scrotum. The congenital form of cryptorchidism is one of the most prevalent urogenital anomalies in male newborns. In the acquired form of cryptorchidism, the testis that was previously descended normally is no longer located in the scrotum. Cryptorchidism is associated with an increased risk of infertility and testicular germ cell tumors. However, data on pubertal progression are less well-established because of the limited number of studies. Here, we aim to review the currently available data on pubertal development in boys with a history of non-syndromic cryptorchidism-both congenital and acquired cryptorchidism. The review is focused on the timing of puberty, physical changes, testicular growth, and endocrine development during puberty. The available evidence demonstrated that the timing of the onset of puberty in boys with a history of congenital cryptorchidism does not differ from that of non-cryptorchid boys. Hypothalamic-pituitary-gonadal hormone measurements showed an impaired function or fewer Sertoli cells and/or germ cells among boys with a history of cryptorchidism, particularly with a history of bilateral cryptorchidism treated with orchiopexy. Leydig cell function is generally not affected in boys with a history of cryptorchidism. Data on pubertal development among boys with acquired cryptorchidism are lacking; therefore, more research is needed to investigate pubertal progression among such boys.
摘要：
隐睾是指一个或两个睾丸未充分下降到阴囊中的情况。隐睾的先天性形式是男性新生儿中最常见的泌尿生殖系统异常之一。以后天的隐睾形式，以前正常下降的睾丸不再位于阴囊中。隐睾与不育和睾丸生殖细胞肿瘤的风险增加有关。然而,由于研究数量有限,有关青春期进展的数据尚不完善.这里,我们的目的是回顾现有的关于有非综合征性隐睾病史-先天性和获得性隐睾病史的男孩青春期发育的数据.审查的重点是青春期的时机，物理变化,睾丸生长,和青春期内分泌发育。现有证据表明，有先天性隐睾病史的男孩青春期的发病时间与非隐睾男孩没有区别。下丘脑-垂体-性腺激素测量显示，在有隐睾病史的男孩中，功能受损或支持细胞和/或生殖细胞减少，特别是有双侧隐睾病史的睾丸固定术。在有隐睾病史的男孩中，睾丸间质细胞的功能通常不会受到影响。缺乏关于获得性隐睾男孩青春期发育的数据；因此，需要更多的研究来调查此类男孩的青春期进展。
