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Abstract：
Pancreatic ductal adenocarcinoma (PDAC) and ampullary carcinoma (AAC) are lethal malignancies with modest benefits from surgery. SOX2 and STIM1 have been linked to anticancer activity in several human malignancies. This study included 94 tumor cases: 48 primary PDAC, 25 metastatic PDAC, and 21 primary AAC with corresponding non-tumor tissue. All cases were immunohistochemically stained for STIM1 and SOX2 and results were correlated with clinicopathologic data, patient survival, and BCL2 immunostaining results. Results revealed that STIM1 and SOX2 epithelial/stromal expressions were significantly higher in PDAC and AAC in comparison to the control groups. STIM1 and SOX2 expressions were positively correlated in the primary and metastatic PDAC (P = 0.016 and, P = 0.001, respectively). However, their expressions were not significantly associated with BCL2 expression. SOX2 epithelial/stromal expressions were positively correlated with the large tumor size in the primary AAC group (P = 0.052, P = 0.044, respectively). STIM1 stromal and SOX2 epithelial over-expressions had a bad prognostic impact on the overall survival of AAC (P = 0.002 and P = 0.001, respectively). Therefore, STIM1 and SOX2 co-expression in tumor cells and intra-tumoral stroma could contribute to the development of PDAC and AAC. STIM1/SOX2 expression is linked to a bad prognosis in AAC.
摘要：
胰腺导管腺癌（PDAC）和壶腹癌（AAC）是致命的恶性肿瘤，手术获益不大。SOX2和STIM1与几种人类恶性肿瘤的抗癌活性有关。本研究包括94例肿瘤：48例原发性PDAC，25转移性PDAC，和21个原发性AAC与相应的非肿瘤组织。所有病例均行STIM1和SOX2免疫组化染色，结果与临床病理资料相关。患者生存,和BCL2免疫染色结果。结果表明，与对照组相比，PDAC和AAC中的STIM1和SOX2上皮/基质表达明显更高。STIM1和SOX2在原发性和转移性PDAC中的表达呈正相关(P=0.016,分别为P=0.001)。然而,它们的表达与BCL2表达无显著相关性。原发AAC组SOX2上皮/间质表达与肿瘤大小呈正相关(P=0.052,P=0.044)。STIM1基质和SOX2上皮过表达对AAC的总体生存具有不良的预后影响（分别为P=0.002和P=0.001）。因此,STIM1和SOX2在肿瘤细胞和肿瘤内基质中的共表达可能有助于PDAC和AAC的发展。STIM1/SOX2表达与AAC的不良预后有关。
