METHODS: This was an unmatched case-control study conducted between January 2021 and January 2022. The sample size was estimated to be a total of 434 women (217 with prolapse as cases and 217 without prolapse as controls). Data comparisons were made using the Chi-Square and Student T tests. Binary and multivariate logistic regressions were used to determine associated factors. A p < 0.05 was considered significant.
RESULTS: Variables identified as definitive predictors of pelvic organ prolapse included low BMI (aOR 2.991; CI 1.419-6.307; p = 0.004), home birth (aOR 6.102; CI 3.526-10.561; p < 0.001), family history of POP (aOR 2.085; CI 1.107-3.924; p = 0.023), history of birth without an episiotomy (aOR 3.504; CI 2.031-6.048; p = 0), height ≤ 150 cm (aOR 5.328; CI 2.942-9.648; p < 0.001) and history of giving birth to a macrosomic baby (aOR 1.929; IC 1.121-3.321; p = 0.018).
CONCLUSIONS: This study identified that Body Mass Index and birth-related factors are definitive predictors of pelvic organ prolapse in a low-resource setting. These factors are potentially modifiable and should be targeted in any future pelvic organ prolapse prevention policy. Additionally, there seems to be a genetic predisposition for prolapse, which warrants further assessment in specifically designed large scale studies.
方法:这是一项在2021年1月至2022年1月之间进行的无与伦比的病例对照研究。样本量估计为434名妇女(217例有脱垂,217例无脱垂作为对照)。使用卡方和学生T检验进行数据比较。二元和多元逻辑回归用于确定相关因素。P<0.05被认为是显著的。
结果:确定为盆腔器官脱垂的决定性预测因子的变量包括低BMI(aOR2.991;CI1.419-6.307;p=0.004),家庭分娩(AOR6.102;CI3.526-10.561;p<0.001),POP家族史(aOR2.085;CI1.107-3.924;p=0.023),无会阴切开术的出生史(aOR3.504;CI2.031-6.048;p=0),身高≤150厘米(aOR5.328;CI2.942-9.648;p<0.001)和生育大体性婴儿的历史(aOR1.929;IC1.121-3.321;p=0.018)。
结论:这项研究发现,体重指数和出生相关因素是低资源环境下盆腔器官脱垂的决定性预测因素。这些因素可能是可改变的,应在未来的任何盆腔器官脱垂预防政策中作为目标。此外,似乎有脱垂的遗传倾向,这需要在专门设计的大规模研究中进行进一步评估。