PDF(Pubmed)
Abstract：
BACKGROUND: The widespread application of extracorporeal membrane oxygenation (ECMO) has enhanced clinical outcomes for patients experiencing cardiac arrest. However, its effectiveness is still limited and falls short of the desired level. Therapeutic hypothermia, which maintains body temperatures between 32°C and 36°C in cardiac arrest patients treated with ECMO, has been proposed as a potential means of neuroprotection and increased survival rates. Nevertheless, it remains controversial, and its impact on patient complications has yet to be fully understood. Thus, this paper aims to update the protocol for a systematic review of patients treated with ECMO and therapeutic hypothermia, in order to explore its effects on survival and neurological function.
METHODS: This protocol has been developed in compliance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols 2015. The following databases will be systematically searched: PubMed, Web of Science, Cochrane Library, Embase, Ovid, CNKI, Wanfang and China Biology Medicine Disc. The database search strategy will use a combination of subject terms and free-text keywords. The search will encompass articles from the inception of each database up to 15 June 2023. Inclusion criteria encompass randomised controlled trials, cohort studies, case-control studies and quasi-experimental studies. Two researchers will independently review articles and extract relevant data based on these criteria. Any disagreements will be resolved through discussion. Data analysis will be performed using Review Manager software.
BACKGROUND: Since no patient data were collected in this study, ethical approval was not required. Research findings will be released in a peer-reviewed journal.
UNASSIGNED: CRD42023435353.
METHODS: This protocol has been developed in compliance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols 2015. The following databases will be systematically searched: PubMed, Web of Science, Cochrane Library, Embase, Ovid, CNKI, Wanfang and China Biology Medicine Disc. The database search strategy will use a combination of subject terms and free-text keywords. The search will encompass articles from the inception of each database up to 15 June 2023. Inclusion criteria encompass randomised controlled trials, cohort studies, case-control studies and quasi-experimental studies. Two researchers will independently review articles and extract relevant data based on these criteria. Any disagreements will be resolved through discussion. Data analysis will be performed using Review Manager software.
BACKGROUND: Since no patient data were collected in this study, ethical approval was not required. Research findings will be released in a peer-reviewed journal.
UNASSIGNED: CRD42023435353.
摘要：
背景：体外膜氧合（ECMO）的广泛应用提高了心脏骤停患者的临床预后。然而,其有效性仍然有限，达不到预期水平。治疗性低温,在接受ECMO治疗的心脏骤停患者中，其体温保持在32°C至36°C之间，已被提议作为神经保护和提高生存率的潜在手段。然而，它仍然有争议，及其对患者并发症的影响尚未完全了解。因此，本文旨在更新对ECMO和治疗性低温治疗的患者进行系统评价的方案，以探讨其对生存和神经功能的影响。
方法：该方案是根据2015年系统评价和荟萃分析方案的首选报告项目制定的。将系统地搜索以下数据库：PubMed，WebofScience,科克伦图书馆,Embase,奥维德,CNKI,万方与中国生物医药光盘。数据库搜索策略将使用主题词和自由文本关键字的组合。搜索将涵盖从每个数据库开始到2023年6月15日的文章。纳入标准包括随机对照试验，队列研究，病例对照研究和准实验研究。两名研究人员将根据这些标准独立审查文章并提取相关数据。任何分歧都将通过讨论解决。使用ReviewManager软件进行数据分析。
背景：由于本研究未收集患者数据，不需要伦理批准。研究结果将在同行评审的期刊上发布。
■CRD42023435353。
方法：该方案是根据2015年系统评价和荟萃分析方案的首选报告项目制定的。将系统地搜索以下数据库：PubMed，WebofScience,科克伦图书馆,Embase,奥维德,CNKI,万方与中国生物医药光盘。数据库搜索策略将使用主题词和自由文本关键字的组合。搜索将涵盖从每个数据库开始到2023年6月15日的文章。纳入标准包括随机对照试验，队列研究，病例对照研究和准实验研究。两名研究人员将根据这些标准独立审查文章并提取相关数据。任何分歧都将通过讨论解决。使用ReviewManager软件进行数据分析。
背景：由于本研究未收集患者数据，不需要伦理批准。研究结果将在同行评审的期刊上发布。
■CRD42023435353。
