PDF(Pubmed)
Abstract：
The aim of this research is to explore the therapeutic efficacy of platelet-rich plasma (PRP) on the cutaneous ulceration of diabetes mellitus (DM). From the beginning of the database until January 2024, we looked through several databases to obtain randomised, controlled PRP studies to treat the wound healing of DM in adult patients. The Cochrane Collaboration\'s Risk-Of-Bias Instrument was used to evaluate the risk of bias in randomised, controlled studies. Funnel plots, sensitivity analyses and Egger regression tests were employed to determine the reliability and effectiveness of the meta-analyses. Depending on the degree of heterogeneity, a fixed or random effect model has been used. The statistical significance was determined to be below 0.05. Altogether 281 trials were collected from the database and entered into Endnote Software for screening, and 15 trials were analysed. It was found that PRP was associated with a higher rate of wound healing (OR, 3.23; 95% CI, 2.42, 4.31 p < 0.0001). PRP was associated with a reduction in the risk of post-operative wound infection (OR, 0.46; 95% CI, 0.21, 0.99 p = 0.05). PRP was associated with a reduction in the risk of amputations amongst those with DM (OR, 0.50; 95% CI, 0.30, 0.84 p = 0.009). Overall, PRP treatment for DM is expected to improve the rate of wound healing, decrease the risk of wound infection and decrease the risk of amputations.
摘要：
本研究的目的是探讨富血小板血浆（PRP）对糖尿病（DM）皮肤溃疡的治疗效果。从数据库开始到2024年1月，我们浏览了几个数据库，以获得随机的，治疗成年患者DM伤口愈合的对照PRP研究。CochraneCollaboration的风险偏倚工具用于评估随机偏倚的风险，对照研究。漏斗地块,采用敏感性分析和Egger回归检验来确定meta分析的可靠性和有效性.根据异质性的程度，已经使用了固定或随机效应模型。统计显著性被确定为低于0.05。总共从数据库中收集了281项试验，并将其输入Endnote软件进行筛选，并对15项试验进行了分析。发现PRP与较高的伤口愈合率(OR，3.23；95%CI，2.42，4.31p<0.0001)。PRP与术后伤口感染风险的降低相关（OR，0.46；95%CI，0.21，0.99p=0.05）。PRP与DM患者截肢风险降低相关(OR，0.50；95%CI，0.30，0.84p=0.009）。总的来说,PRP治疗DM有望提高伤口愈合率，降低伤口感染的风险，降低截肢的风险。
