PDF(Pubmed)
Abstract：
BACKGROUND: Nasal rhinosporidiosis refers to a rare chronic granulomatous disease caused by Rhinosporidium seeberi. It affects the mucous membrane of sites such as nasopharynx, conjunctiva and palate. Inverted papillomas are relatively rare and are benign epithelial tumors of the nasal cavity that are locally aggressive, exhibit recurrence tendency and malignant transformation. Both entities are very rare in our setting and this is perhaps the first documented case in Tanzania.
METHODS: The patient was a 7-year old boy with a 1-year history of left-sided nasal obstruction and intermittent epistaxis for 6 months. He had no history of cheek swelling, pain or numbness, loss or loosening of teeth or alveolar ridge fullness. There were no ophthalmological, otological or neurological complaints reported. Endoscopic excision of the nasal mass was done and histopathological analysis confirmed co-existence of rhinosporidiosis and inverted papilloma. Postoperatively, the patient was kept on oral dapsone at a dose of 50 mg/day for 6-months and with no residual disease recurrence noted after 6-months follow up.
UNASSIGNED: The patient underwent endoscopic excision of the nasal mass and histopathological analysis confirmed co-existence of rhinosporidiosis and inverted papilloma. Postoperatively, the patient was kept on oral dapsone at a dose of 50 mg/day for 6-months and with no residual disease recurrence noted after 6-months of follow up.
CONCLUSIONS: Nasal rhinosporidiosis and inverted papilloma lesions may resemble the routinely encountered nasal polyps thus important for both clinicians and pathologists to have a high index of suspicion when managing patients with nasal masses even from non-endemic areas.
METHODS: The patient was a 7-year old boy with a 1-year history of left-sided nasal obstruction and intermittent epistaxis for 6 months. He had no history of cheek swelling, pain or numbness, loss or loosening of teeth or alveolar ridge fullness. There were no ophthalmological, otological or neurological complaints reported. Endoscopic excision of the nasal mass was done and histopathological analysis confirmed co-existence of rhinosporidiosis and inverted papilloma. Postoperatively, the patient was kept on oral dapsone at a dose of 50 mg/day for 6-months and with no residual disease recurrence noted after 6-months follow up.
UNASSIGNED: The patient underwent endoscopic excision of the nasal mass and histopathological analysis confirmed co-existence of rhinosporidiosis and inverted papilloma. Postoperatively, the patient was kept on oral dapsone at a dose of 50 mg/day for 6-months and with no residual disease recurrence noted after 6-months of follow up.
CONCLUSIONS: Nasal rhinosporidiosis and inverted papilloma lesions may resemble the routinely encountered nasal polyps thus important for both clinicians and pathologists to have a high index of suspicion when managing patients with nasal masses even from non-endemic areas.
摘要：
背景：鼻鼻孢子虫病是指一种罕见的慢性肉芽肿性疾病，由雪柏鼻虫引起。它影响鼻咽等部位的粘膜，结膜和腭。内翻性乳头状瘤相对罕见，是鼻腔良性上皮性肿瘤，具有局部侵袭性，表现出复发倾向和恶变。这两个实体在我们的环境中都非常罕见，这可能是坦桑尼亚第一个有记录的案例。
方法：患者为一名7岁男孩，有1年左侧鼻塞和间歇性鼻出血6个月的病史。他没有脸颊肿胀的病史，疼痛或麻木，牙齿脱落或松动或牙槽嵴丰满。没有眼科检查，耳科或神经科投诉报告。完成了鼻肿块的内窥镜切除，组织病理学分析证实了鼻孢子虫病和内翻性乳头状瘤并存。术后,患者口服氨苯砜,剂量为50mg/d,持续6个月,随访6个月后未发现残留疾病复发.
■患者接受鼻内镜切除鼻块，组织病理学分析证实鼻孢子虫病和内翻性乳头状瘤并存。术后,患者口服氨苯砜,剂量为50mg/d,持续6个月,随访6个月后未发现残留疾病复发.
结论：鼻鼻孢子虫病和内翻性乳头状瘤病变可能与常规鼻息肉相似，因此对于临床医生和病理学家来说，在处理鼻腔肿块的患者时，即使是非地方区域也要高度怀疑。
方法：患者为一名7岁男孩，有1年左侧鼻塞和间歇性鼻出血6个月的病史。他没有脸颊肿胀的病史，疼痛或麻木，牙齿脱落或松动或牙槽嵴丰满。没有眼科检查，耳科或神经科投诉报告。完成了鼻肿块的内窥镜切除，组织病理学分析证实了鼻孢子虫病和内翻性乳头状瘤并存。术后,患者口服氨苯砜,剂量为50mg/d,持续6个月,随访6个月后未发现残留疾病复发.
■患者接受鼻内镜切除鼻块，组织病理学分析证实鼻孢子虫病和内翻性乳头状瘤并存。术后,患者口服氨苯砜,剂量为50mg/d,持续6个月,随访6个月后未发现残留疾病复发.
结论：鼻鼻孢子虫病和内翻性乳头状瘤病变可能与常规鼻息肉相似，因此对于临床医生和病理学家来说，在处理鼻腔肿块的患者时，即使是非地方区域也要高度怀疑。
