Abstract：
Chlorination is the common antifouling method in desalination and power plant water intake structures to control microbial and macrofouling growth. In this study, the impacts of chlorine dioxide on toxicity, metabolic activity and biochemical markers like glutathione S-transferase and catalase enzyme activity were tested using four zooplankton species (Centropages sp., Acartia sp., Oncaea sp., and Calanus sp.) collected from the Red Sea. The zooplankton species were treated with different concentrations (0.02, 0.05, 0.1, 0.2, and 0.5 mg L-1) of chlorine dioxide. Further, chlorite, the main decomposition product of chlorine dioxide, was used for molecular docking studies against glutathione S-transferase and catalase enzymes. The results indicated the LC50 range of 0.552-1.643 mg L-1 for the studied zooplankton species. The respiration rate of the zooplankton increased due to the chlorine dioxide treatment with a maximum of 0.562 μg O2 copepod h-1 in Acartia. The glutathione S-transferase and catalase enzyme activities showed elevated values in zooplankton treated with chlorine dioxide. Molecular docking of chlorite with enzymes involved in antioxidant defense activity, such as glutathione S-transferase and catalase enzyme showed weak interactions. Overall, this study yielded significant insights for understanding the effects of chlorine dioxide on the survival, metabolism, and biochemical composition of marine zooplankton.
摘要：
氯化是海水淡化和电厂取水结构中常见的防污方法，可控制微生物和大型污垢的生长。在这项研究中,二氧化氯对毒性的影响，使用四种浮游动物物种（Centropagessp.,Acartiasp.,Oncaeasp.,和Calanussp.）从红海收集。用不同浓度（0.02、0.05、0.1、0.2和0.5mgL-1）的二氧化氯处理浮游动物物种。Further,绿泥石,二氧化氯的主要分解产物，用于针对谷胱甘肽S-转移酶和过氧化氢酶的分子对接研究。结果表明，所研究的浮游动物物种的LC50范围为0.552-1.643mgL-1。由于二氧化氯处理，浮游动物的呼吸速率增加，Acartia中最大为0.562μgO2co足类h-1。在用二氧化氯处理的浮游动物中，谷胱甘肽S-转移酶和过氧化氢酶活性显示出升高的值。亚氯酸盐与参与抗氧化防御活性的酶的分子对接，谷胱甘肽S-转移酶和过氧化氢酶等酶表现出微弱的相互作用。总的来说,这项研究为了解二氧化氯对生存的影响提供了重要的见解，新陈代谢，和海洋浮游动物的生化组成。
