Abstract：
The process of wound healing necessitates a specific environment, thus prompting extensive research into the utilization of hydrogels for this purpose. While numerous hydrogel structures have been investigated, the discovery of a self-healing hydrogel possessing favorable biocompatibility, exceptional mechanical properties, and effective hemostatic and antibacterial performance remains uncommon. In this work, a polyvinyl alcohol (PVA) hybrid hydrogel was meticulously designed through a simple reaction, wherein CuxO anchored sepiolite was incorporated into the hydrogel. The results indicate that introduction of sepiolite greatly improves the toughness, self-healing and adhesion properties of the PVA hydrogels. CuxO nanoparticles endow the hydrogels with excellent antibacterial performance towards Staphylococcus aureus and Escherichia coli. The application of hybrid hydrogels for fast hemostasis and wound healing are verified in vitro and in vivo with rat experiments. This work thereby demonstrates an effective strategy for designing biodegradable hemostatic and wound healing materials.
摘要：
伤口愈合的过程需要特定的环境，因此，促使人们对为此目的利用水凝胶进行广泛的研究。虽然已经研究了许多水凝胶结构，发现一种具有良好生物相容性的自修复水凝胶，特殊的机械性能，有效的止血和抗菌性能仍然不常见。在这项工作中,通过简单的反应精心设计了聚乙烯醇（PVA）混合水凝胶，其中CuxO锚定的海泡石被并入水凝胶中。结果表明，海泡石的引入大大提高了韧性，PVA水凝胶的自修复和粘附性能。CuxO纳米粒子赋予水凝胶对金黄色葡萄球菌和大肠杆菌具有优异的抗菌性能。通过大鼠实验在体外和体内验证了混合水凝胶在快速止血和伤口愈合中的应用。因此，这项工作证明了设计可生物降解的止血和伤口愈合材料的有效策略。
