PDF(Pubmed)
Abstract：
Infertility is a widespread global issue that affects approximately 15% of sexually active and active couples, which contributes to about 50% of cases. Currently, the condition remains prevalent and often inadequately treated. This systematic review aims to evaluate existing studies investigating the effects of probiotic supplementation in men. A comprehensive search was conducted across major databases, including PubMed, Cochrane, Science Direct, and Scielo, using relevant keywords such as \'probiotic\' OR \'Lactobacillus\' OR \'Bifidobacterium\' AND \'Male infertility\' OR \'male fertility\' OR \'sperm quality\' OR \'sperm motility\' OR \'oligoasthenoteratozoospermia\' and their Portuguese equivalents. Four randomized clinical studies met the inclusion criteria, focusing on men diagnosed with idiopathic male infertility (oligozoospermia, teratozoospermia, and asthenozoospermia). The findings revealed that probiotic administration exhibited promising antioxidant properties by combating reactive oxygen species (ROS), consequently protecting sperm DNA from damage that correlates with declining sperm quality. Significant improvements were observed across all sperm parameters, with notable enhancement in motility. Consequently, probiotic supplementation emerges as a potential therapeutic alternative for men diagnosed with idiopathic infertility, demonstrating positive effects on sperm quality.
摘要：
不孕症是一个普遍的全球性问题，影响到大约15％的性活跃和活跃的夫妇，这导致了大约50%的病例。目前,这种情况仍然很普遍，而且往往得不到充分的治疗。本系统综述旨在评估现有研究，调查益生菌补充剂对男性的影响。对各大数据库进行了全面检索,包括PubMed,科克伦,科学直接，和Scielo,使用相关关键词，如\'益生菌\'或\'乳杆菌\'或\'双歧杆菌\'和\'男性不育\'或\'男性生育能力\'或\'精子质量\'或\'精子活力\'或\'或\'少弱精子症\'及其葡萄牙语等价物。四项随机临床研究符合纳入标准，专注于诊断为特发性男性不育症的男性（少精子症，畸形精子症,和弱精子症）。研究结果表明，益生菌的给药通过对抗活性氧（ROS）表现出有希望的抗氧化性能，因此，保护精子DNA免受与精子质量下降相关的损伤。在所有精子参数中观察到显着改善，运动能力显著增强。因此,益生菌补充剂是诊断为特发性不孕症的男性的潜在治疗替代方案，对精子质量有积极影响。
