PDF(Pubmed)
Abstract：
To investigate the effect of reduced early-pregnancy activated partial thrombin time (APTT), prothrombin time (PT), and international standardized ratio (INR) on the risk of preeclampsia. A total of 8549 pregnant women with singleton births were included. Early pregnancy APTT, PT, and INR levels, with age, birth, prepregnancy body mass index, fibrinogen (FBG), thrombin time (TT), D-dimer (DD2), antithrombin III (ATIII), fibrin degradation products (FDP) as confounders, generalized linear model of APTT, the relative risk of PT and INR when INR reduction. After adequate adjustment for confounders, the relative risk of preeclampsia was 0.703 for every 1 s increase in plasma PT results in early pregnancy, and for every 0.1 increase in plasma INR results, the relative risk of preeclampsia was 0.767. With a PT less than the P25 quantile (<11 s), the relative risk of preeclampsia was 1.328. The relative risk of preeclampsia at an INR less than the P25 quantile (<0.92) was 1.24. There was no statistical association between APTT on the risk of preeclampsia. The relative risk of preeclampsia is strongly associated with a decrease in PT and INR in early pregnancy. PT and INR in early pregnancy were a potential marker in the risk stratification of preeclampsia. Focusing on reduced PT and INR levels in early pregnancy can help to identify early pregnancies at risk for preeclampsia.
摘要：
探讨降低早孕活化部分凝血酶时间(APTT)的效果,凝血酶原时间（PT），和国际标准化比率（INR）对先兆子痫的风险。总共包括8549名单胎孕妇。早孕APTT,PT,和INR水平，随着年龄,出生,孕前体重指数,纤维蛋白原（FBG），凝血酶时间（TT），D-二聚体(DD2),抗凝血酶III（ATIII），纤维蛋白降解产物(FDP)作为混杂因素，APTT的广义线性模型，INR降低时PT和INR的相对风险。在对混杂因素进行充分调整后，妊娠早期血浆PT结果每增加1s，先兆子痫的相对风险为0.703，血浆INR结果每增加0.1,先兆子痫的相对风险为0.767.PT小于P25分位数(<11s)，先兆子痫的相对风险为1.328.INR小于P25分位数（<0.92）时先兆子痫的相对风险为1.24。APTT与先兆子痫风险之间没有统计学关联。先兆子痫的相对风险与妊娠早期PT和INR的降低密切相关。妊娠早期的PT和INR是先兆子痫危险分层的潜在标志。关注妊娠早期PT和INR水平的降低可以帮助识别有先兆子痫风险的早期妊娠。
