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Abstract：
BACKGROUND: This study aimed to analyze the life expectancy and cause of death in osteoarthritis (OA) patients who underwent total knee arthroplasty (TKA) and to identify risk factors that affect long-term mortality rate after TKA.
METHODS: Among 601 patients, who underwent primary TKA due to OA by a single surgeon from July 2005 to December 2011, we identified patients who died after the operation using data obtained from the National Statistical Office of Korea. We calculated 5-, 10-, and 15-year survival rates of the patients and age-specific standardized mortality ratios (SMRs) compared to general population of South Korea according to the causes of death. We also identified risk factors for death.
RESULTS: The 5-year, 10-year, and 15-year survival rates were 94%, 84%, and 75%, respectively. The overall age-specific SMR of the TKA cohort was lower than that of the general population (0.69; P < 0.001). Cause-specific SMRs for circulatory diseases, neoplasms, and digestive diseases after TKA were significantly lower than those of the general population (0.65, 0.58, and 0.16, respectively; all P < 0.05). Male gender, older age, lower body mass index (BMI), anemia, and higher Charlson comorbidity index (CCI) were significant factors associated with higher mortality after TKA.
CONCLUSIONS: TKA is a worthwhile surgery that can improve life expectancy, especially from diseases of the circulatory system, neoplasms, and digestive system, in patients with OA compared to the general population. However, careful follow-up is needed for patients with male gender, older age, lower BMI, anemia, and higher CCI, as these factors may increase long-term mortality risk after TKA.
METHODS: III.
METHODS: Among 601 patients, who underwent primary TKA due to OA by a single surgeon from July 2005 to December 2011, we identified patients who died after the operation using data obtained from the National Statistical Office of Korea. We calculated 5-, 10-, and 15-year survival rates of the patients and age-specific standardized mortality ratios (SMRs) compared to general population of South Korea according to the causes of death. We also identified risk factors for death.
RESULTS: The 5-year, 10-year, and 15-year survival rates were 94%, 84%, and 75%, respectively. The overall age-specific SMR of the TKA cohort was lower than that of the general population (0.69; P < 0.001). Cause-specific SMRs for circulatory diseases, neoplasms, and digestive diseases after TKA were significantly lower than those of the general population (0.65, 0.58, and 0.16, respectively; all P < 0.05). Male gender, older age, lower body mass index (BMI), anemia, and higher Charlson comorbidity index (CCI) were significant factors associated with higher mortality after TKA.
CONCLUSIONS: TKA is a worthwhile surgery that can improve life expectancy, especially from diseases of the circulatory system, neoplasms, and digestive system, in patients with OA compared to the general population. However, careful follow-up is needed for patients with male gender, older age, lower BMI, anemia, and higher CCI, as these factors may increase long-term mortality risk after TKA.
METHODS: III.
摘要：
背景：本研究旨在分析接受全膝关节置换术（TKA）的骨关节炎（OA）患者的预期寿命和死亡原因，并确定影响TKA术后长期死亡率的危险因素。
方法：在601名患者中，在2005年7月至2011年12月期间,一名外科医生因OA接受了原发性TKA治疗的患者中,我们使用从韩国国家统计局获得的数据确定了手术后死亡的患者.我们计算了5-，10-,根据死亡原因，与韩国普通人群相比，患者的15年生存率和年龄特异性标准化死亡率（SMR）。我们还确定了死亡的危险因素。
结果：5年，10年,15年生存率为94%，84%,75%,分别。TKA队列的总体年龄特异性SMR低于一般人群(0.69;P<0.001)。针对循环系统疾病的特定原因SMR，肿瘤，TKA术后消化系统疾病发生率明显低于普通人群(分别为0.65、0.58、0.16,均P<0.05)。男性,年龄较大,较低的体重指数（BMI），贫血,和较高的Charlson合并症指数(CCI)是TKA术后死亡率较高的显著相关因素。
结论：TKA是一种值得的手术，可以提高预期寿命，尤其是循环系统疾病，肿瘤，和消化系统,与一般人群相比，OA患者。然而,男性患者需要仔细随访，年龄较大,较低的BMI,贫血,和更高的CCI，因为这些因素可能会增加TKA后的长期死亡风险。
方法：III.
方法：在601名患者中，在2005年7月至2011年12月期间,一名外科医生因OA接受了原发性TKA治疗的患者中,我们使用从韩国国家统计局获得的数据确定了手术后死亡的患者.我们计算了5-，10-,根据死亡原因，与韩国普通人群相比，患者的15年生存率和年龄特异性标准化死亡率（SMR）。我们还确定了死亡的危险因素。
结果：5年，10年,15年生存率为94%，84%,75%,分别。TKA队列的总体年龄特异性SMR低于一般人群(0.69;P<0.001)。针对循环系统疾病的特定原因SMR，肿瘤，TKA术后消化系统疾病发生率明显低于普通人群(分别为0.65、0.58、0.16,均P<0.05)。男性,年龄较大,较低的体重指数（BMI），贫血,和较高的Charlson合并症指数(CCI)是TKA术后死亡率较高的显著相关因素。
结论：TKA是一种值得的手术，可以提高预期寿命，尤其是循环系统疾病，肿瘤，和消化系统,与一般人群相比，OA患者。然而,男性患者需要仔细随访，年龄较大,较低的BMI,贫血,和更高的CCI，因为这些因素可能会增加TKA后的长期死亡风险。
方法：III.
