PDF(Pubmed)
Abstract：
UNASSIGNED: Connexin 43 (Cx43) is the main gap junction (GJ) protein and hemichannel protein in bone tissue. It is involved in the formation of hemichannels and GJs and establishes channels that can communicate directly to exchange substances and signals, affecting the structure and function of osteocytes. CX43 is very important for the normal development of bone tissue and the establishment and balance of bone reconstruction. However, the molecular mechanisms by which CX43 regulates osteoblast function and homeostasis have been less well studied, and this article provides a review of research in this area.
UNASSIGNED: We searched the PubMed, EMBASE, Cochrane Library, and Web of Science databases for studies published up to June 2023 using the keywords Connexin 43/Cx43 and Osteocytes. Screening of literatures according to inclusion and exclusion guidelines and summarized the results.
UNASSIGNED: Osteocytes, osteoblasts, and osteoclasts all express Cx43 and form an overall network through the interaction between GJs. Cx43 is not only involved in the mechanical response of bone tissue but also in the regulation of signal transduction, which could provide new molecular markers and novel targets for the treatment of certain bone diseases.
UNASSIGNED: Cx43 is expressed in osteoblasts, osteoclasts, and osteoclasts and plays an important role in regulating the function, signal transduction, and mechanotransduction of osteocytes. This review offers a new contribution to the literature by summarizing the relationship between Cx43, a key protein of bone tissue, and osteoblasts.
UNASSIGNED: We searched the PubMed, EMBASE, Cochrane Library, and Web of Science databases for studies published up to June 2023 using the keywords Connexin 43/Cx43 and Osteocytes. Screening of literatures according to inclusion and exclusion guidelines and summarized the results.
UNASSIGNED: Osteocytes, osteoblasts, and osteoclasts all express Cx43 and form an overall network through the interaction between GJs. Cx43 is not only involved in the mechanical response of bone tissue but also in the regulation of signal transduction, which could provide new molecular markers and novel targets for the treatment of certain bone diseases.
UNASSIGNED: Cx43 is expressed in osteoblasts, osteoclasts, and osteoclasts and plays an important role in regulating the function, signal transduction, and mechanotransduction of osteocytes. This review offers a new contribution to the literature by summarizing the relationship between Cx43, a key protein of bone tissue, and osteoblasts.
摘要：
■连接蛋白43（Cx43）是骨组织中的主要缝隙连接（GJ）蛋白和半通道蛋白。它参与半通道和GJ的形成，并建立可以直接通信以交换物质和信号的渠道，影响骨细胞的结构和功能。CX43对于骨组织的正常发育和骨重建的建立和平衡非常重要。然而,CX43调节成骨细胞功能和体内平衡的分子机制研究较少，本文对该领域的研究进行了综述。
■我们搜索了PubMed，EMBASE,科克伦图书馆,和WebofScience数据库，使用关键字Connexin43/Cx43和骨细胞进行截至2023年6月的研究。根据纳入和排除指南筛选文献并总结结果。
■骨细胞，成骨细胞，和破骨细胞都表达Cx43，并通过GJ之间的相互作用形成一个整体网络。Cx43不仅参与骨组织的力学响应,还参与信号转导的调节,可以为某些骨病的治疗提供新的分子标记和新的靶点。
■Cx43在成骨细胞中表达，破骨细胞,和破骨细胞，在调节功能中起着重要作用，信号转导，和骨细胞的机械传导。这篇综述通过总结骨组织的关键蛋白Cx43之间的关系，为文献提供了新的贡献。和成骨细胞。
■我们搜索了PubMed，EMBASE,科克伦图书馆,和WebofScience数据库，使用关键字Connexin43/Cx43和骨细胞进行截至2023年6月的研究。根据纳入和排除指南筛选文献并总结结果。
■骨细胞，成骨细胞，和破骨细胞都表达Cx43，并通过GJ之间的相互作用形成一个整体网络。Cx43不仅参与骨组织的力学响应,还参与信号转导的调节,可以为某些骨病的治疗提供新的分子标记和新的靶点。
■Cx43在成骨细胞中表达，破骨细胞,和破骨细胞，在调节功能中起着重要作用，信号转导，和骨细胞的机械传导。这篇综述通过总结骨组织的关键蛋白Cx43之间的关系，为文献提供了新的贡献。和成骨细胞。
