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Abstract：
UNASSIGNED: Recurrence rate of Helicobacter pylori (H. pylori) infection after successful eradication have gained attention. This study was to assess the recurrence rate of H. pylori infection after successful eradication in the southern coastal provinces of China and to analyze its factors.
UNASSIGNED: 975 patients with upper gastrointestinal symptoms who were diagnosed with H. pylori infection using the 13C or 14C-urea breath test (UBT) underwent eradication treatment between August 2021 and December 2022. After eight to twelve weeks, repeat UBT was performed. Besides, 824 patients with successful eradication underwent a repeat UBT by completing questionnaires after a year. The 1-year recurrence rate was calculated, and the differences were analyzed based on baseline data, sociological characteristics, and lifestyle.
UNASSIGNED: A total of 734 patients completed the 1-year follow-up, out of which 26 (3.5%) patients experienced a recurrence of H. pylori infection. Exposure to other individuals infected with H. pylori (χ2=12.852, P<0.001), poor hygiene conditions at dining out places (χ2=6.839, P=0.009), frequent dining out (χ2=24.315, P<0.001), smoking (χ2=7.510, P=0.006), consumption of non-purified water (χ2=16.437, P<0.001), consumption of pickled foods (χ2=5.682, P=0.017), irregular meal patterns (χ2=16.877, P<0.001) and age (χ2=9.195, P=0.010) were significant factors for H. pylori infection recurrence. Exposure to other individuals infected with H. pylori, poor hygiene conditions at dining out places, consumption of non-purified water, frequent dining out and irregular meal patterns were independent risk factors (P=0.022, 0.016, 0.002, <0.001, <0.001; 95% CI 0.146-0.861, 0.121-0.806, 1.715-10.845, 0.085-0.521, 2.291-14.556).
UNASSIGNED: The one-year recurrence rate of H. pylori infection post-eradication in the southern coastal provinces of China is 3.5%. Contacting with infected individuals, poor hygiene in dining places, consumption of non-purified water, frequent dining out, and irregular meal patterns were identified as significant independent factors influencing H. pylori recurrence.
UNASSIGNED: 975 patients with upper gastrointestinal symptoms who were diagnosed with H. pylori infection using the 13C or 14C-urea breath test (UBT) underwent eradication treatment between August 2021 and December 2022. After eight to twelve weeks, repeat UBT was performed. Besides, 824 patients with successful eradication underwent a repeat UBT by completing questionnaires after a year. The 1-year recurrence rate was calculated, and the differences were analyzed based on baseline data, sociological characteristics, and lifestyle.
UNASSIGNED: A total of 734 patients completed the 1-year follow-up, out of which 26 (3.5%) patients experienced a recurrence of H. pylori infection. Exposure to other individuals infected with H. pylori (χ2=12.852, P<0.001), poor hygiene conditions at dining out places (χ2=6.839, P=0.009), frequent dining out (χ2=24.315, P<0.001), smoking (χ2=7.510, P=0.006), consumption of non-purified water (χ2=16.437, P<0.001), consumption of pickled foods (χ2=5.682, P=0.017), irregular meal patterns (χ2=16.877, P<0.001) and age (χ2=9.195, P=0.010) were significant factors for H. pylori infection recurrence. Exposure to other individuals infected with H. pylori, poor hygiene conditions at dining out places, consumption of non-purified water, frequent dining out and irregular meal patterns were independent risk factors (P=0.022, 0.016, 0.002, <0.001, <0.001; 95% CI 0.146-0.861, 0.121-0.806, 1.715-10.845, 0.085-0.521, 2.291-14.556).
UNASSIGNED: The one-year recurrence rate of H. pylori infection post-eradication in the southern coastal provinces of China is 3.5%. Contacting with infected individuals, poor hygiene in dining places, consumption of non-purified water, frequent dining out, and irregular meal patterns were identified as significant independent factors influencing H. pylori recurrence.
摘要：
■幽门螺杆菌的复发率(H.成功根除后的pylori)感染得到了关注。本研究旨在评估中国南部沿海省份成功根除幽门螺杆菌后的复发率，并分析其影响因素。
■975例使用13C或14C-尿素呼气试验（UBT）诊断为幽门螺杆菌感染的上消化道症状患者在2021年8月至2022年12月之间接受了根除治疗。八到十二周后，重复进行UBT。此外,成功根除的824例患者在一年后通过填写问卷进行了重复UBT。计算1年复发率，并根据基线数据分析差异，社会学特征，和生活方式。
■共有734名患者完成了为期1年的随访，其中26例(3.5%)患者出现幽门螺杆菌感染复发。其他感染幽门螺杆菌的个体暴露(χ2=12.852,P<0.001),外出就餐场所卫生条件差(χ2=6.839,P=0.009),经常外出就餐(χ2=24.315,P<0.001),吸烟(χ2=7.510,P=0.006),非纯净水消耗量(χ2=16.437,P<0.001),腌制食品的消费量（χ2=5.682，P=0.017），饮食不规律(χ2=16.877,P<0.001)和年龄(χ2=9.195,P=0.010)是幽门螺杆菌感染复发的重要因素。暴露于感染幽门螺杆菌的其他个体，外出就餐的卫生条件差，消耗非纯净水，频繁外出就餐和不规律进餐模式是独立危险因素(P=0.022,0.016,0.002,<0.001,<0.001;95%CI0.146-0.861,0.121-0.806,1.715-10.845,0.085-0.521,2.291-14.556)。
■中国南部沿海省份根除幽门螺杆菌感染后一年复发率为3.5%。与感染者接触，餐饮场所卫生条件差，消耗非纯净水，经常外出就餐,和不规则膳食模式被确定为影响幽门螺杆菌复发的显著独立因素。
■975例使用13C或14C-尿素呼气试验（UBT）诊断为幽门螺杆菌感染的上消化道症状患者在2021年8月至2022年12月之间接受了根除治疗。八到十二周后，重复进行UBT。此外,成功根除的824例患者在一年后通过填写问卷进行了重复UBT。计算1年复发率，并根据基线数据分析差异，社会学特征，和生活方式。
■共有734名患者完成了为期1年的随访，其中26例(3.5%)患者出现幽门螺杆菌感染复发。其他感染幽门螺杆菌的个体暴露(χ2=12.852,P<0.001),外出就餐场所卫生条件差(χ2=6.839,P=0.009),经常外出就餐(χ2=24.315,P<0.001),吸烟(χ2=7.510,P=0.006),非纯净水消耗量(χ2=16.437,P<0.001),腌制食品的消费量（χ2=5.682，P=0.017），饮食不规律(χ2=16.877,P<0.001)和年龄(χ2=9.195,P=0.010)是幽门螺杆菌感染复发的重要因素。暴露于感染幽门螺杆菌的其他个体，外出就餐的卫生条件差，消耗非纯净水，频繁外出就餐和不规律进餐模式是独立危险因素(P=0.022,0.016,0.002,<0.001,<0.001;95%CI0.146-0.861,0.121-0.806,1.715-10.845,0.085-0.521,2.291-14.556)。
■中国南部沿海省份根除幽门螺杆菌感染后一年复发率为3.5%。与感染者接触，餐饮场所卫生条件差，消耗非纯净水，经常外出就餐,和不规则膳食模式被确定为影响幽门螺杆菌复发的显著独立因素。
