UNASSIGNED: 975 patients with upper gastrointestinal symptoms who were diagnosed with H. pylori infection using the 13C or 14C-urea breath test (UBT) underwent eradication treatment between August 2021 and December 2022. After eight to twelve weeks, repeat UBT was performed. Besides, 824 patients with successful eradication underwent a repeat UBT by completing questionnaires after a year. The 1-year recurrence rate was calculated, and the differences were analyzed based on baseline data, sociological characteristics, and lifestyle.
UNASSIGNED: A total of 734 patients completed the 1-year follow-up, out of which 26 (3.5%) patients experienced a recurrence of H. pylori infection. Exposure to other individuals infected with H. pylori (χ2=12.852, P<0.001), poor hygiene conditions at dining out places (χ2=6.839, P=0.009), frequent dining out (χ2=24.315, P<0.001), smoking (χ2=7.510, P=0.006), consumption of non-purified water (χ2=16.437, P<0.001), consumption of pickled foods (χ2=5.682, P=0.017), irregular meal patterns (χ2=16.877, P<0.001) and age (χ2=9.195, P=0.010) were significant factors for H. pylori infection recurrence. Exposure to other individuals infected with H. pylori, poor hygiene conditions at dining out places, consumption of non-purified water, frequent dining out and irregular meal patterns were independent risk factors (P=0.022, 0.016, 0.002, <0.001, <0.001; 95% CI 0.146-0.861, 0.121-0.806, 1.715-10.845, 0.085-0.521, 2.291-14.556).
UNASSIGNED: The one-year recurrence rate of H. pylori infection post-eradication in the southern coastal provinces of China is 3.5%. Contacting with infected individuals, poor hygiene in dining places, consumption of non-purified water, frequent dining out, and irregular meal patterns were identified as significant independent factors influencing H. pylori recurrence.
■975例使用13C或14C-尿素呼气试验(UBT)诊断为幽门螺杆菌感染的上消化道症状患者在2021年8月至2022年12月之间接受了根除治疗。八到十二周后,重复进行UBT。此外,成功根除的824例患者在一年后通过填写问卷进行了重复UBT。计算1年复发率,并根据基线数据分析差异,社会学特征,和生活方式。
■共有734名患者完成了为期1年的随访,其中26例(3.5%)患者出现幽门螺杆菌感染复发。其他感染幽门螺杆菌的个体暴露(χ2=12.852,P<0.001),外出就餐场所卫生条件差(χ2=6.839,P=0.009),经常外出就餐(χ2=24.315,P<0.001),吸烟(χ2=7.510,P=0.006),非纯净水消耗量(χ2=16.437,P<0.001),腌制食品的消费量(χ2=5.682,P=0.017),饮食不规律(χ2=16.877,P<0.001)和年龄(χ2=9.195,P=0.010)是幽门螺杆菌感染复发的重要因素。暴露于感染幽门螺杆菌的其他个体,外出就餐的卫生条件差,消耗非纯净水,频繁外出就餐和不规律进餐模式是独立危险因素(P=0.022,0.016,0.002,<0.001,<0.001;95%CI0.146-0.861,0.121-0.806,1.715-10.845,0.085-0.521,2.291-14.556)。
■中国南部沿海省份根除幽门螺杆菌感染后一年复发率为3.5%。与感染者接触,餐饮场所卫生条件差,消耗非纯净水,经常外出就餐,和不规则膳食模式被确定为影响幽门螺杆菌复发的显著独立因素。