PDF(Pubmed)
Abstract：
UNASSIGNED: People frequently complain of long-term constipation. The cost associated with using modern medications to treat constipation is significant, and the probability of encountering side effects is notably high. These limitations restrict their effectiveness in therapy, remain unresolved, and underscore the need for research on alternative therapeutic approaches. Plants of the genus Artemisia have been used to treat constipation. Therefore, the aim of this study was to evaluate the laxative effects of aqueous A. abyssinica leaf and stem extracts of Artemisia abyssinica in mice.
UNASSIGNED: The laxative activity of A. abyssinica leaf and stem extracts was evaluated using three models: laxative activity, gastrointestinal motility, and gastrointestinal secretion. In this study, bisacodyl was used as a standard laxative and loperamide was used to induce constipation.
UNASSIGNED: In the laxative test, 200 (P<0.05) and 400 mg/kg (p<0.01) doses of plant extract significantly increased the percentage of fecal water content. Moreover, the highest dose of extract increased the frequency of defecation after 12 h (p<0.05). In the remaining two models, the experimental plans also showed significantly higher gastrointestinal motility and noticeable accumulation of intestinal fluid.
UNASSIGNED: The results of this study indicate that aqueous leaf and stem extracts of A. abyssinica have laxative effects.
UNASSIGNED: The laxative activity of A. abyssinica leaf and stem extracts was evaluated using three models: laxative activity, gastrointestinal motility, and gastrointestinal secretion. In this study, bisacodyl was used as a standard laxative and loperamide was used to induce constipation.
UNASSIGNED: In the laxative test, 200 (P<0.05) and 400 mg/kg (p<0.01) doses of plant extract significantly increased the percentage of fecal water content. Moreover, the highest dose of extract increased the frequency of defecation after 12 h (p<0.05). In the remaining two models, the experimental plans also showed significantly higher gastrointestinal motility and noticeable accumulation of intestinal fluid.
UNASSIGNED: The results of this study indicate that aqueous leaf and stem extracts of A. abyssinica have laxative effects.
摘要：
■人们经常抱怨长期便秘。使用现代药物治疗便秘的成本是巨大的，并且遇到副作用的可能性非常高。这些限制限制了它们在治疗中的有效性，仍未解决，并强调需要研究替代治疗方法。蒿属植物已用于治疗便秘。因此,这项研究的目的是评估水的A.abysicia叶和茎提取物对小鼠的泻药作用。
■使用三种模型评估了深参叶和茎提取物的泻药活性：泻药活性，胃肠蠕动,和胃肠分泌。在这项研究中,比沙可啶被用作标准泻药，洛哌丁胺被用于诱发便秘。
■在泻药试验中，200（P<0.05）和400mg/kg（p<0.01）剂量的植物提取物显着增加了粪便含水量的百分比。此外，最高剂量的提取物增加了12h后排便的频率（p<0.05）。在剩下的两个模型中，实验计划还显示出明显更高的胃肠蠕动和明显的肠液积累。
■这项研究的结果表明，A.abysinica的水性叶和茎提取物具有通便作用。
■使用三种模型评估了深参叶和茎提取物的泻药活性：泻药活性，胃肠蠕动,和胃肠分泌。在这项研究中,比沙可啶被用作标准泻药，洛哌丁胺被用于诱发便秘。
■在泻药试验中，200（P<0.05）和400mg/kg（p<0.01）剂量的植物提取物显着增加了粪便含水量的百分比。此外，最高剂量的提取物增加了12h后排便的频率（p<0.05）。在剩下的两个模型中，实验计划还显示出明显更高的胃肠蠕动和明显的肠液积累。
■这项研究的结果表明，A.abysinica的水性叶和茎提取物具有通便作用。
