PDF(Pubmed)
Abstract：
Objective: The healthcare system needs a novel approach to improve and diagnose early oropharyngeal squamous cell carcinoma against its low survival rate. We conduct a systematic review and a comprehensive meta-analysis for the diagnostic role of blood and salivary microRNAs (miRNAs). Methods: An unbiased and thorough literature search in PubMed yielded appropriate data from qualified articles regarding different miRNA biomarkers, method of extraction, research location, and year of publication. Stata was used to calculate the sensitivity, specificity, diagnostic odds ratio, and summary receiver operating characteristic curve. Results: We included 9 studies with 399 qualified oropharyngeal squamous cell carcinoma patients, which yielded a high diagnostic accuracy of blood miRNAs in combination with salivary miRNAs with a sensitivity of 0.70 (p < 0.001), specificity of 0.75 (p = 0.26), diagnostic odds ratio of 7, and an area under the curve of 0.78. Conclusion: Combined blood- and saliva-derived miRNAs demonstrated a high diagnostic accuracy in detecting oropharyngeal squamous cell carcinoma. Systematic review registration: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024509424.
摘要：
目的：医疗保健系统需要一种新的方法来改善和诊断早期口咽鳞状细胞癌，以防止其低生存率。我们对血液和唾液microRNAs（miRNAs）的诊断作用进行了系统评价和综合荟萃分析。方法：在PubMed中进行无偏见和彻底的文献检索，从合格的文章中获得了有关不同miRNA生物标志物的适当数据。提取方法,研究地点,和出版年份。Stata被用来计算灵敏度，特异性，诊断赔率比，并总结接收器工作特性曲线。结果：我们纳入了9项研究，其中399例合格的口咽鳞癌患者，血液miRNAs联合唾液miRNAs的诊断准确率高，灵敏度为0.70（p<0.001），特异性为0.75(p=0.26)，诊断比值比为7，曲线下面积为0.78。结论：血液和唾液来源的miRNAs联合检测口咽鳞癌具有较高的诊断准确性。系统审查注册：https://www。crd.约克。AC.uk/prospro/display_record.php?ID=CRD42024509424。
