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Abstract：
Cutaneous squamous cell carcinoma (CSCC) is the second most common type of skin cancer, after basal cell carcinoma, representing about 10-20% of all malignant skin tumors. The mortality rates of CSCC approach those of renal and oropharyngeal carcinomas, as well as melanoma, with the increasing of the risk once metastases and perineural invasion occur. Both actinic keratosis (AK) and Bowen\'s disease (BD) are direct precursors with the potential for progression to CSCC. In this study, we analyzed the expression of Ki67, P16 and Beta-catenin in the precursor lesions of CSCC in relation to histological prognostic parameters, respectively between them, with the aim of identifying possible correlations with a role in prognosis. Ki67 and P16 presented higher scores in advanced precancerous lesions, such as keratinocyte intraepithelial neoplasia (KIN) III and BD and low scores in seborrheic keratosis (SK). The immunoreactivity to the investigated markers confirms the multistage skin carcinogenesis, and their involvement starting from the initiation phase of the cancer process. The importance of the studied markers in the evolution and prognosis of precancerous lesions of CSCC is also supported by the linear correlations revealed between the immunoexpressions of P16, Ki67 and the membranous immunoexpression of Beta-catenin in AK.
摘要：
皮肤鳞状细胞癌（CSCC）是第二常见的皮肤癌类型，在基底细胞癌之后，约占所有恶性皮肤肿瘤的10-20％。CSCC的死亡率接近肾癌和口咽癌，以及黑色素瘤，随着一旦发生转移和神经周浸润的风险增加。光化性角化病(AK)和Bowen病(BD)都是有可能发展为CSCC的直接前兆。在这项研究中,我们分析了Ki67，P16和β-catenin在CSCC前体病变中的表达与组织学预后参数的关系，分别在它们之间，目的是确定与预后作用的可能相关性。Ki67和P16在晚期癌前病变中得分较高，如角质形成细胞上皮内瘤变（KIN）III和BD，脂溢性角化病（SK）得分低。对所研究标记的免疫反应性证实了多阶段皮肤癌的发生，以及它们从癌症过程的起始阶段开始的参与。所研究的标志物在CSCC癌前病变的演变和预后中的重要性也得到了AK中P16，Ki67免疫表达与β-catenin膜免疫表达之间的线性相关的支持。
