Abstract：
BACKGROUND: Autoimmune liver diseases (ALDs) are chronic conditions generated by an immune-mediated autoaggressive inflammatory reaction in genetically susceptible individuals. The purpose of this study was to evaluate the prevalence of apical periodontitis (AP) in patients suffering from ALDs undergoing treatment with the immune suppressants glucocorticoids, azathioprine, and/or ursodeoxycholic acid.
METHODS: The ALD group included 46 patients (11 men and 35 women, average age = 57.9 ± 11.8 years) and 1186 teeth. The control group included 50 healthy patients not taking any medications (15 men and 35 women, average age = 58.6 ± 10.4 years) and 1251 teeth. Demographic data and medical, pharmacologic, and dental history were recorded. Dental and radiographic examinations were performed. The presence of AP; the periapical index score; decayed, missing, and filled teeth; quality of restoration, and root canal treatment were evaluated. The influence of the medications the patients were taking on the prevalence of AP was also tested.
RESULTS: The prevalence of AP was significantly lower in ALDs than in the control group at the patient (P = .019) and tooth level (P = .014). Smoking and age were associated with a significant increase in AP in cases and controls (P = .045 and P = .001, respectively). In both groups, endodontically treated teeth showed a higher prevalence of AP.
CONCLUSIONS: Considering the limitations because of the observational nature of the study, the patients affected by ALDs liver diseases and undergoing treatment with immune suppressors (often associated with immune modulators) were found to exhibit a lower prevalence of AP.
METHODS: The ALD group included 46 patients (11 men and 35 women, average age = 57.9 ± 11.8 years) and 1186 teeth. The control group included 50 healthy patients not taking any medications (15 men and 35 women, average age = 58.6 ± 10.4 years) and 1251 teeth. Demographic data and medical, pharmacologic, and dental history were recorded. Dental and radiographic examinations were performed. The presence of AP; the periapical index score; decayed, missing, and filled teeth; quality of restoration, and root canal treatment were evaluated. The influence of the medications the patients were taking on the prevalence of AP was also tested.
RESULTS: The prevalence of AP was significantly lower in ALDs than in the control group at the patient (P = .019) and tooth level (P = .014). Smoking and age were associated with a significant increase in AP in cases and controls (P = .045 and P = .001, respectively). In both groups, endodontically treated teeth showed a higher prevalence of AP.
CONCLUSIONS: Considering the limitations because of the observational nature of the study, the patients affected by ALDs liver diseases and undergoing treatment with immune suppressors (often associated with immune modulators) were found to exhibit a lower prevalence of AP.
摘要：
背景：自身免疫性肝病（ALD）是遗传易感个体中由免疫介导的自身侵袭性炎症反应产生的慢性病症。这项研究的目的是评估患有ALDs的患者接受免疫抑制剂糖皮质激素治疗的根尖周炎（AP）的患病率。硫唑嘌呤，和/或熊去氧胆酸。
方法：ALD组包括46名患者（11名男性和35名女性，平均年龄=57.9±11.8岁）和1186颗牙齿。对照组包括50名不服用任何药物的健康患者（15名男性和35名女性，平均年龄=58.6±10.4岁）和1251颗牙齿。人口数据和医疗，药理学,并记录牙科病史。进行牙科和影像学检查。AP的存在；根尖指数评分；腐烂，失踪,和填充的牙齿；修复质量，并对根管治疗进行评价。还测试了患者服用的药物对AP患病率的影响。
结果：在患者（P=0.019）和牙齿水平（P=0.014），ALDs的AP患病率明显低于对照组。在病例和对照组中，吸烟和年龄与AP的显着增加相关（分别为P=.045和P=.001）。在这两组中,经牙髓治疗的牙齿显示AP患病率较高.
结论：考虑到该研究的观察性限制，发现患有ALDs肝病并接受免疫抑制剂(通常与免疫调节剂相关)治疗的患者AP患病率较低.
方法：ALD组包括46名患者（11名男性和35名女性，平均年龄=57.9±11.8岁）和1186颗牙齿。对照组包括50名不服用任何药物的健康患者（15名男性和35名女性，平均年龄=58.6±10.4岁）和1251颗牙齿。人口数据和医疗，药理学,并记录牙科病史。进行牙科和影像学检查。AP的存在；根尖指数评分；腐烂，失踪,和填充的牙齿；修复质量，并对根管治疗进行评价。还测试了患者服用的药物对AP患病率的影响。
结果：在患者（P=0.019）和牙齿水平（P=0.014），ALDs的AP患病率明显低于对照组。在病例和对照组中，吸烟和年龄与AP的显着增加相关（分别为P=.045和P=.001）。在这两组中,经牙髓治疗的牙齿显示AP患病率较高.
结论：考虑到该研究的观察性限制，发现患有ALDs肝病并接受免疫抑制剂(通常与免疫调节剂相关)治疗的患者AP患病率较低.
