CONCLUSIONS: Patient-derived renal progenitors can be isolated from urine to set up proper disease modeling. This strategy allows to make diagnosis of genetic kidney disease in patients carrying unknown significance variants or uncover variants missed from peripheral blood analysis. Furthermore, urinary-derived tubuloids obtained from renal progenitors of patients appear to be potentially valuable for modeling kidney diseases to test ex vivo treatment efficacy or to develop new therapeutic approaches. Finally, renal progenitors derived from urine can provide insights into acute kidney injury and predict kidney function recovery and outcome.
CONCLUSIONS: Renal progenitors derived from urine are a promising new noninvasive and easy-to-handle tool, which improves the rate of diagnosis and the therapeutic choice, paving the way toward a personalized healthcare.
结论:可以从尿液中分离出患者来源的肾祖细胞,以建立适当的疾病模型。该策略允许对携带未知显著性变异或从外周血分析中遗漏的发现变异的患者进行遗传性肾病的诊断。此外,从患者的肾祖细胞中获得的尿衍生的肾小管样蛋白似乎对于模拟肾脏疾病以测试离体治疗功效或开发新的治疗方法具有潜在的价值。最后,来自尿液的肾祖细胞可以提供对急性肾损伤的见解,并预测肾功能恢复和预后。
结论:来自尿液的肾祖细胞是一种有希望的新型非侵入性和易于操作的工具,这提高了诊断率和治疗选择,为个性化医疗保健铺平道路。