Abstract：
BACKGROUND: Chronic kidney disease affects 10% of the world population, and it is associated with progression to end-stage kidney disease and increased morbidity and mortality. The advent of multi-omics technologies has expanded our knowledge on the complexity of kidney diseases, revealing their frequent genetic etiology, particularly in children and young subjects. Genetic heterogeneity and drug screening require patient-derived disease models to establish a correct diagnosis and evaluate new potential treatments and outcomes.
CONCLUSIONS: Patient-derived renal progenitors can be isolated from urine to set up proper disease modeling. This strategy allows to make diagnosis of genetic kidney disease in patients carrying unknown significance variants or uncover variants missed from peripheral blood analysis. Furthermore, urinary-derived tubuloids obtained from renal progenitors of patients appear to be potentially valuable for modeling kidney diseases to test ex vivo treatment efficacy or to develop new therapeutic approaches. Finally, renal progenitors derived from urine can provide insights into acute kidney injury and predict kidney function recovery and outcome.
CONCLUSIONS: Renal progenitors derived from urine are a promising new noninvasive and easy-to-handle tool, which improves the rate of diagnosis and the therapeutic choice, paving the way toward a personalized healthcare.
CONCLUSIONS: Patient-derived renal progenitors can be isolated from urine to set up proper disease modeling. This strategy allows to make diagnosis of genetic kidney disease in patients carrying unknown significance variants or uncover variants missed from peripheral blood analysis. Furthermore, urinary-derived tubuloids obtained from renal progenitors of patients appear to be potentially valuable for modeling kidney diseases to test ex vivo treatment efficacy or to develop new therapeutic approaches. Finally, renal progenitors derived from urine can provide insights into acute kidney injury and predict kidney function recovery and outcome.
CONCLUSIONS: Renal progenitors derived from urine are a promising new noninvasive and easy-to-handle tool, which improves the rate of diagnosis and the therapeutic choice, paving the way toward a personalized healthcare.
摘要：
背景：慢性肾脏病影响10%的世界人口，它与进展为终末期肾脏病和增加的发病率和死亡率有关。多组学技术的出现扩大了我们对肾脏疾病复杂性的认识,揭示了他们常见的遗传病因，特别是在年轻的科目。遗传异质性和药物筛选需要患者来源的疾病模型来建立正确的诊断并评估新的潜在治疗方法和结果。
结论：可以从尿液中分离出患者来源的肾祖细胞，以建立适当的疾病模型。该策略允许对携带未知显著性变异或从外周血分析中遗漏的发现变异的患者进行遗传性肾病的诊断。此外，从患者的肾祖细胞中获得的尿衍生的肾小管样蛋白似乎对于模拟肾脏疾病以测试离体治疗功效或开发新的治疗方法具有潜在的价值。最后,来自尿液的肾祖细胞可以提供对急性肾损伤的见解，并预测肾功能恢复和预后。
结论：来自尿液的肾祖细胞是一种有希望的新型非侵入性和易于操作的工具，这提高了诊断率和治疗选择，为个性化医疗保健铺平道路。
结论：可以从尿液中分离出患者来源的肾祖细胞，以建立适当的疾病模型。该策略允许对携带未知显著性变异或从外周血分析中遗漏的发现变异的患者进行遗传性肾病的诊断。此外，从患者的肾祖细胞中获得的尿衍生的肾小管样蛋白似乎对于模拟肾脏疾病以测试离体治疗功效或开发新的治疗方法具有潜在的价值。最后,来自尿液的肾祖细胞可以提供对急性肾损伤的见解，并预测肾功能恢复和预后。
结论：来自尿液的肾祖细胞是一种有希望的新型非侵入性和易于操作的工具，这提高了诊断率和治疗选择，为个性化医疗保健铺平道路。
