Hippo 信号控制的 MHC I 类抗原加工和呈递途径增强了抗肿瘤免疫力。
关键词: CP: Cancer CP: Immunology Hippo pathway MHC class I NLRC5 NuRD complex TAZ TEAD YAP antigen processing and presentation antitumor immunity immune checkpoint blockade
Mesh : Animals Antigen Presentation / immunology Histocompatibility Antigens Class I / metabolism immunology genetics Humans Hippo Signaling Pathway Mice Signal Transduction Protein Serine-Threonine Kinases / metabolism YAP-Signaling Proteins / metabolism Cell Line, Tumor Adaptor Proteins, Signal Transducing / metabolism genetics Neoplasms / immunology pathology metabolism Mice, Inbred C57BL CD8-Positive T-Lymphocytes / immunology metabolism Intracellular Signaling Peptides and Proteins / metabolism genetics T-Lymphocytes, Cytotoxic / immunology Transcription Factors / metabolism
来 源: DOI:10.1016/j.celrep.2024.114003