PDF(Pubmed)
Abstract：
BACKGROUND: Basaloid salivary tumors can demonstrate significant morphologic overlap and be challenging to diagnose.
METHODS: A review of select ancillary studies in basaloid salivary tumors was performed.
RESULTS: A number of immunohistochemical stains, including PLAG1, HMGA2, β-catenin, MYB, and RAS Q61R, have been more recently incorporated into the diagnostic workup of basaloid salivary tumors.
CONCLUSIONS: Although reported variability in their performance has perhaps limited their widespread adoption, these immunohistochemical studies can nevertheless be useful in supporting pathologic diagnoses, particularly when considered in more specific differentials or when used as a panel with other markers.
METHODS: A review of select ancillary studies in basaloid salivary tumors was performed.
RESULTS: A number of immunohistochemical stains, including PLAG1, HMGA2, β-catenin, MYB, and RAS Q61R, have been more recently incorporated into the diagnostic workup of basaloid salivary tumors.
CONCLUSIONS: Although reported variability in their performance has perhaps limited their widespread adoption, these immunohistochemical studies can nevertheless be useful in supporting pathologic diagnoses, particularly when considered in more specific differentials or when used as a panel with other markers.
摘要：
背景：基底样涎腺肿瘤可表现出显著的形态学重叠，诊断具有挑战性。
方法：对基底样涎腺肿瘤的部分辅助研究进行综述。
结果：一些免疫组织化学染色，包括PLAG1，HMGA2，β-catenin，MYB,和RASQ61R，最近已被纳入基底类唾液肿瘤的诊断检查中。
结论：尽管报告的性能变化可能限制了它们的广泛采用，然而，这些免疫组织化学研究可用于支持病理诊断，特别是在更具体的差异中考虑或与其他标记物一起用作面板时。
方法：对基底样涎腺肿瘤的部分辅助研究进行综述。
结果：一些免疫组织化学染色，包括PLAG1，HMGA2，β-catenin，MYB,和RASQ61R，最近已被纳入基底类唾液肿瘤的诊断检查中。
结论：尽管报告的性能变化可能限制了它们的广泛采用，然而，这些免疫组织化学研究可用于支持病理诊断，特别是在更具体的差异中考虑或与其他标记物一起用作面板时。
