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Abstract：
BACKGROUND: Docetaxel, cisplatin, and 5-fluorouracil (DCF) chemotherapy is reportedly an effective treatment strategy for squamous cell carcinoma of the anus (SCCA). However, studies regarding its use in Japanese patients remain scarce.
METHODS: Here, we present the case of an 82-year-old woman with SCCA, cStage IIIB. Chemoradiotherapy was initiated after colostomy of the anorectal mass; however, para-aortic lymph node recurrence was observed 3 months after treatment completion. Five courses of DCF chemotherapy were subsequently administered, resulting in a complete response (CR). Two years and 1 month later, the aortic lymph node was enlarged again, and the patient achieved CR again after radiotherapy. Nine months later, local recurrence was detected in the anal canal, and laparoscopic perineal rectal amputation was performed. The patient remains progression-free 5 years and 10 months after the initial treatment and 1 year and 7 months after the final treatment.
CONCLUSIONS: Our findings suggest that complementary treatment after DCF chemotherapy may be efficacious in Japanese patients with SCCA and help achieve CR. Despite occasional local recurrences, this approach may help achieve long-term progression-free survival.
METHODS: Here, we present the case of an 82-year-old woman with SCCA, cStage IIIB. Chemoradiotherapy was initiated after colostomy of the anorectal mass; however, para-aortic lymph node recurrence was observed 3 months after treatment completion. Five courses of DCF chemotherapy were subsequently administered, resulting in a complete response (CR). Two years and 1 month later, the aortic lymph node was enlarged again, and the patient achieved CR again after radiotherapy. Nine months later, local recurrence was detected in the anal canal, and laparoscopic perineal rectal amputation was performed. The patient remains progression-free 5 years and 10 months after the initial treatment and 1 year and 7 months after the final treatment.
CONCLUSIONS: Our findings suggest that complementary treatment after DCF chemotherapy may be efficacious in Japanese patients with SCCA and help achieve CR. Despite occasional local recurrences, this approach may help achieve long-term progression-free survival.
摘要：
背景：多西他赛，顺铂,据报道，5-氟尿嘧啶（DCF）化疗是肛门鳞状细胞癌（SCCA）的有效治疗策略。然而,关于其在日本患者中使用的研究仍然很少。
方法：这里，我们介绍了一个82岁的SCCA患者，cStageIIIB。在肛门直肠肿块结肠造口术后开始放化疗；然而，治疗完成后3个月观察到主动脉旁淋巴结复发.随后进行了五个疗程的DCF化疗，产生完整的响应(CR)。两年零一个月后,主动脉淋巴结再次增大,放疗后患者再次达到CR。九个月后,在肛管中检测到局部复发，并进行了腹腔镜会阴直肠截肢术。患者在初始治疗后5年和10个月以及最终治疗后1年和7个月保持无进展。
结论：我们的研究结果表明，DCF化疗后的补充治疗可能对日本SCCA患者有效，并有助于实现CR。尽管偶尔局部复发，这种方法可能有助于实现长期无进展生存期.
方法：这里，我们介绍了一个82岁的SCCA患者，cStageIIIB。在肛门直肠肿块结肠造口术后开始放化疗；然而，治疗完成后3个月观察到主动脉旁淋巴结复发.随后进行了五个疗程的DCF化疗，产生完整的响应(CR)。两年零一个月后,主动脉淋巴结再次增大,放疗后患者再次达到CR。九个月后,在肛管中检测到局部复发，并进行了腹腔镜会阴直肠截肢术。患者在初始治疗后5年和10个月以及最终治疗后1年和7个月保持无进展。
结论：我们的研究结果表明，DCF化疗后的补充治疗可能对日本SCCA患者有效，并有助于实现CR。尽管偶尔局部复发，这种方法可能有助于实现长期无进展生存期.
