Abstract：
Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus that affects both children and adults. Symptoms in adults are mainly esophageal dysphagia, which ranges from mild symptoms to acute food bolus obstruction of the esophagus. Diagnosis is defined as symptoms of esophageal dysfunction and ≥ 15 eosinophils/high power field (HPF) in at least one of the biopsies taken from the esophagus. EoE appears to be increasing in both prevalence and incidence. The aim of this study was to investigate the prevalence, incidence, and presenting symptoms of patients with EoE within the catchment area of Northern Älvsborg County Hospital in Trollhättan. Patient records with the ICD code of EoE between 2012 and 2022 and pathology reports from esophageal biopsies from 2000-2022 were examined. Patients with symptoms of esophageal dysfunction and > 15 eosinophils/HPF were classified as having EoE. In total, 409 EoE patients (379 adults and 30 children) fulfilled the diagnostic criteria during the follow-up period. The overall prevalence was 113 cases/100 000 inhabitants (adults 127/100 000 and children 57/100 000) at 31 December 2022. The incidence was 7/100 000 and increased during the observation period. At diagnosis, 46% of the adults and 11% of the children had a history of acute bolus obstruction requiring hospitalization, while 51% of adults and 22% of children exhibited endoscopic findings of fibrosis. The prevalence of EoE is significantly higher than that generally reported in an area of southwest Sweden. The results indicate that the incidence is increasing; however, whether this is due to an actual increase or heightened awareness of EoE is inconclusive. Acute bolus obstruction is a common presenting symptom among EoE patients and is most likely an effect of late diagnosis.
摘要：
嗜酸性粒细胞性食管炎（EoE）是一种影响儿童和成人的食道慢性炎症。成人的症状主要是食道吞咽困难，范围从轻度症状到食道急性食团阻塞。诊断定义为食管功能障碍的症状和至少一次取自食管的活检中≥15个嗜酸性粒细胞/高倍视野（HPF）。EoE的患病率和发病率似乎都在增加。这项研究的目的是调查患病率，发病率,并在Trollhättan的Northernälvsborg县医院的集水区出现EoE患者的症状。检查2012年至2022年ICD代码为EoE的患者记录以及2000年至2022年食管活检的病理报告。具有食管功能障碍症状和>15个嗜酸性粒细胞/HPF的患者被分类为患有EoE。总的来说,409例EoE患者（379名成人和30名儿童）在随访期间符合诊断标准。截至2022年12月31日，总体患病率为113例/100.000居民（成人127/100.000和儿童57/100.000）。发病率为7/100.000，在观察期间有所增加。诊断时,46％的成年人和11％的儿童有需要住院治疗的急性丸剂阻塞史，而51%的成人和22%的儿童表现出纤维化的内镜表现.EoE的患病率明显高于瑞典西南部地区的普遍报道。结果表明，发病率正在增加；然而，这是否是由于EoE意识的实际增加或提高，目前尚无定论。急性推注阻塞是EoE患者中常见的症状，很可能是晚期诊断的结果。
