METHODS: A retrospective analysis of a 12-month prospective follow-up study patients with stable COPD undergoing standardized treatment, covering mild to severe stages, was conducted. The baseline and follow-up assessments included computed tomography and body plethysmography.
RESULTS: This study included 35 patients (17 females and 18 males). This study revealed that females had more stable LF but tended to have greater declines in SMM areas and indices than males (-5.4% vs. -1.9%, respectively), despite the fact that females were younger and had higher LF and less exacerbation than males. A multivariate linear regression showed a negative association between the inspiratory capacity/total lung capacity ratio (IC/TLC) and muscle fat area.
CONCLUSIONS: The findings suggest distinct LF and BC progression patterns between male and female patients with COPD. A low IC/TLC ratio may predict increased muscle fat. Further studies are necessary to understand these relationships better.
方法:对接受标准化治疗的稳定期COPD患者进行为期12个月的前瞻性随访研究的回顾性分析,涵盖轻度至重度阶段,进行了。基线和随访评估包括计算机断层扫描和身体体积描记术。
结果:本研究包括35名患者(17名女性和18名男性)。这项研究表明,女性的LF更稳定,但SMM面积和指数的下降幅度大于男性(-5.4%vs.-1.9%,分别),尽管女性比男性年轻,LF更高,恶化程度更低。多元线性回归显示,吸气量/总肺活量比(IC/TLC)与肌肉脂肪面积之间呈负相关。
结论:研究结果表明,男性和女性COPD患者之间存在不同的LF和BC进展模式。低IC/TLC比率可以预测增加的肌肉脂肪。需要进一步的研究才能更好地理解这些关系。