PDF(Pubmed)
Abstract：
BACKGROUND: Patients with chronic obstructive pulmonary disease (COPD) with low skeletal muscle mass and severe airway obstruction have higher mortality risks. However, the relationship between dynamic/static lung function (LF) and thoracic skeletal muscle measurements (SMM) remains unclear. This study explored patient characteristics (weight, BMI, exacerbations, dynamic/static LF, sex differences in LF and SMM, and the link between LF and SMM changes.
METHODS: A retrospective analysis of a 12-month prospective follow-up study patients with stable COPD undergoing standardized treatment, covering mild to severe stages, was conducted. The baseline and follow-up assessments included computed tomography and body plethysmography.
RESULTS: This study included 35 patients (17 females and 18 males). This study revealed that females had more stable LF but tended to have greater declines in SMM areas and indices than males (-5.4% vs. -1.9%, respectively), despite the fact that females were younger and had higher LF and less exacerbation than males. A multivariate linear regression showed a negative association between the inspiratory capacity/total lung capacity ratio (IC/TLC) and muscle fat area.
CONCLUSIONS: The findings suggest distinct LF and BC progression patterns between male and female patients with COPD. A low IC/TLC ratio may predict increased muscle fat. Further studies are necessary to understand these relationships better.
METHODS: A retrospective analysis of a 12-month prospective follow-up study patients with stable COPD undergoing standardized treatment, covering mild to severe stages, was conducted. The baseline and follow-up assessments included computed tomography and body plethysmography.
RESULTS: This study included 35 patients (17 females and 18 males). This study revealed that females had more stable LF but tended to have greater declines in SMM areas and indices than males (-5.4% vs. -1.9%, respectively), despite the fact that females were younger and had higher LF and less exacerbation than males. A multivariate linear regression showed a negative association between the inspiratory capacity/total lung capacity ratio (IC/TLC) and muscle fat area.
CONCLUSIONS: The findings suggest distinct LF and BC progression patterns between male and female patients with COPD. A low IC/TLC ratio may predict increased muscle fat. Further studies are necessary to understand these relationships better.
摘要：
背景：患有低骨骼肌质量和严重气道阻塞的慢性阻塞性肺疾病（COPD）患者具有更高的死亡风险。然而,动态/静态肺功能(LF)与胸骨骼肌测量(SMM)之间的关系尚不清楚.本研究探讨了患者特征(体重，BMI,恶化,动态/静态LF，LF和SMM的性别差异，和LF和SMM之间的链接改变。
方法：对接受标准化治疗的稳定期COPD患者进行为期12个月的前瞻性随访研究的回顾性分析，涵盖轻度至重度阶段，进行了。基线和随访评估包括计算机断层扫描和身体体积描记术。
结果：本研究包括35名患者（17名女性和18名男性）。这项研究表明，女性的LF更稳定，但SMM面积和指数的下降幅度大于男性（-5.4％vs.-1.9%，分别)，尽管女性比男性年轻，LF更高，恶化程度更低。多元线性回归显示，吸气量/总肺活量比（IC/TLC）与肌肉脂肪面积之间呈负相关。
结论：研究结果表明，男性和女性COPD患者之间存在不同的LF和BC进展模式。低IC/TLC比率可以预测增加的肌肉脂肪。需要进一步的研究才能更好地理解这些关系。
方法：对接受标准化治疗的稳定期COPD患者进行为期12个月的前瞻性随访研究的回顾性分析，涵盖轻度至重度阶段，进行了。基线和随访评估包括计算机断层扫描和身体体积描记术。
结果：本研究包括35名患者（17名女性和18名男性）。这项研究表明，女性的LF更稳定，但SMM面积和指数的下降幅度大于男性（-5.4％vs.-1.9%，分别)，尽管女性比男性年轻，LF更高，恶化程度更低。多元线性回归显示，吸气量/总肺活量比（IC/TLC）与肌肉脂肪面积之间呈负相关。
结论：研究结果表明，男性和女性COPD患者之间存在不同的LF和BC进展模式。低IC/TLC比率可以预测增加的肌肉脂肪。需要进一步的研究才能更好地理解这些关系。
