PDF(Pubmed)
Abstract：
UNASSIGNED: Oculocardiac reflex (OCR) is one of the serious complications following surgical therapeutic procedures for strabismus. Various medications have been tested to prevent or mitigate this complication. We aimed to compare the effect of intravenous atropine and topical tetracaine on the incidence and severity of OCR in strabismus surgery.
UNASSIGNED: In this triple-blind randomized clinical trial study, 120 patients who were candidates for strabismus surgery were randomly assigned to receive intravenous atropine, topical tetracaine, or artificial tears as the control. The incidence of OCR and its severity along with the changes in hemodynamic conditions were compared across the groups.
UNASSIGNED: The incidence rate of OCR in the groups receiving atropine, tetracaine, and the control was found to be 17.5%, 25.0%, and 32.5% in the releasing phase without any difference, respectively (P = 0.303); however, it was 2.5%, 7.5%, and 25.0%, respectively, in the cutting phase, indicating a lower rate in the group receiving tetracaine (P = 0.004). Similarly, there was no difference in the severity of OCR across the three study groups in the releasing phase (P = 0.666); however, in the cutting phase, OCR was revealed to be milder in the group receiving atropine as compared to other groups (P = 0.033). Prescribing atropine led to higher mean systolic blood pressure and mean arterial pressure during surgery.
UNASSIGNED: The injection of atropine can effectively reduce the incidence of OCR during strabismus surgery and reduce its severity if this reflex occurs.
UNASSIGNED: In this triple-blind randomized clinical trial study, 120 patients who were candidates for strabismus surgery were randomly assigned to receive intravenous atropine, topical tetracaine, or artificial tears as the control. The incidence of OCR and its severity along with the changes in hemodynamic conditions were compared across the groups.
UNASSIGNED: The incidence rate of OCR in the groups receiving atropine, tetracaine, and the control was found to be 17.5%, 25.0%, and 32.5% in the releasing phase without any difference, respectively (P = 0.303); however, it was 2.5%, 7.5%, and 25.0%, respectively, in the cutting phase, indicating a lower rate in the group receiving tetracaine (P = 0.004). Similarly, there was no difference in the severity of OCR across the three study groups in the releasing phase (P = 0.666); however, in the cutting phase, OCR was revealed to be milder in the group receiving atropine as compared to other groups (P = 0.033). Prescribing atropine led to higher mean systolic blood pressure and mean arterial pressure during surgery.
UNASSIGNED: The injection of atropine can effectively reduce the incidence of OCR during strabismus surgery and reduce its severity if this reflex occurs.
摘要：
■眼心反射（OCR）是斜视手术治疗后的严重并发症之一。已经测试了各种药物来预防或减轻这种并发症。我们旨在比较静脉阿托品和局部丁卡因对斜视手术中OCR发生率和严重程度的影响。
■在这项三盲随机临床试验研究中，斜视手术的120例患者被随机分配接受静脉阿托品，局部用丁卡因，或人工泪液作为控制。比较各组OCR的发生率及其严重程度以及血液动力学状况的变化。
■接受阿托品治疗组OCR的发生率，丁卡因,控制率为17.5%，25.0%,释放阶段为32.5%，没有任何差异，分别(P=0.303)；然而，是2.5%,7.5%,和25.0%，分别,在切割阶段，表明接受丁卡因组的比率较低（P=0.004）。同样，在释放阶段，三个研究组的OCR严重程度没有差异(P=0.666)；然而，在切割阶段，与其他组相比，接受阿托品的组OCR较温和（P=0.033）。在手术过程中，使用阿托品会导致较高的平均收缩压和平均动脉压。
■注射阿托品可有效降低斜视手术中OCR的发生率，并在发生这种反射的情况下降低其严重程度。
■在这项三盲随机临床试验研究中，斜视手术的120例患者被随机分配接受静脉阿托品，局部用丁卡因，或人工泪液作为控制。比较各组OCR的发生率及其严重程度以及血液动力学状况的变化。
■接受阿托品治疗组OCR的发生率，丁卡因,控制率为17.5%，25.0%,释放阶段为32.5%，没有任何差异，分别(P=0.303)；然而，是2.5%,7.5%,和25.0%，分别,在切割阶段，表明接受丁卡因组的比率较低（P=0.004）。同样，在释放阶段，三个研究组的OCR严重程度没有差异(P=0.666)；然而，在切割阶段，与其他组相比，接受阿托品的组OCR较温和（P=0.033）。在手术过程中，使用阿托品会导致较高的平均收缩压和平均动脉压。
■注射阿托品可有效降低斜视手术中OCR的发生率，并在发生这种反射的情况下降低其严重程度。
