PDF(Pubmed)
Abstract：
UNASSIGNED: Our study aims to determine the incidence and potential risk factors for cerebral radiation necrosis (CRN) following treatment of sinonasal malignancies.
UNASSIGNED: One hundred thirty-two patients diagnosed with sinonasal malignancies over an 18-year period were identified at two institutions. Forty-six patients meeting inclusion criteria and treated with radiation therapy were included for analysis. Demographic and clinical-pathologic characteristics were collected and reviewed. Post-treatment magnetic resonance imaging (MRI) at least 1 year following treatment was reviewed to determine presence or absence of CRN.
UNASSIGNED: CRN was identified on MRI in 8 of 46 patients (17.4%) following radiation treatment. Patients with a history of reirradiation were more likely to develop CRN (50% vs. 10.5%, p < .05). The BEDs of radiation were also higher in CRN patients compared to non-CRN patients, but this difference was not significant (p > .05). CRN patients had a higher proportion of tumors with skull base involvement than non-CRN patients (100% vs. 57.9%, p = .037). Demographics, comorbidities, pathology, primary tumor subsite, chemotherapy use, and stage of disease demonstrated no significant increase in risk of CRN.
UNASSIGNED: Reirradiation and tumor skull base involvement were significant risk factors associated with CRN. Higher average total prescribed and BEDs of radiation were seen in the CRN groups, but these differences were not statistically significant. Gender, comorbidities, tumor subsite, tumor location, and treatment type were not significantly different between groups.
UNASSIGNED: Level 3.
UNASSIGNED: One hundred thirty-two patients diagnosed with sinonasal malignancies over an 18-year period were identified at two institutions. Forty-six patients meeting inclusion criteria and treated with radiation therapy were included for analysis. Demographic and clinical-pathologic characteristics were collected and reviewed. Post-treatment magnetic resonance imaging (MRI) at least 1 year following treatment was reviewed to determine presence or absence of CRN.
UNASSIGNED: CRN was identified on MRI in 8 of 46 patients (17.4%) following radiation treatment. Patients with a history of reirradiation were more likely to develop CRN (50% vs. 10.5%, p < .05). The BEDs of radiation were also higher in CRN patients compared to non-CRN patients, but this difference was not significant (p > .05). CRN patients had a higher proportion of tumors with skull base involvement than non-CRN patients (100% vs. 57.9%, p = .037). Demographics, comorbidities, pathology, primary tumor subsite, chemotherapy use, and stage of disease demonstrated no significant increase in risk of CRN.
UNASSIGNED: Reirradiation and tumor skull base involvement were significant risk factors associated with CRN. Higher average total prescribed and BEDs of radiation were seen in the CRN groups, but these differences were not statistically significant. Gender, comorbidities, tumor subsite, tumor location, and treatment type were not significantly different between groups.
UNASSIGNED: Level 3.
摘要：
■我们的研究旨在确定鼻腔鼻窦恶性肿瘤治疗后脑放射性坏死（CRN）的发生率和潜在危险因素。
■在两个机构中确定了在18年期间诊断为鼻窦恶性肿瘤的132例患者。纳入符合纳入标准并接受放射治疗的46例患者进行分析。收集并审查了人口统计学和临床病理特征。对治疗后至少1年的治疗后磁共振成像（MRI）进行审查，以确定是否存在CRN。
■在放疗后的46例患者中有8例（17.4%）在MRI上发现CRN。有再照射史的患者更有可能发生CRN(50%vs.10.5%,p<.05)。与非CRN患者相比，CRN患者的辐射BED也较高，但这种差异并不显著(p>0.05)。CRN患者颅底受累肿瘤的比例高于非CRN患者(100%vs.57.9%,p=.037）。人口统计,合并症,病理学,原发性肿瘤亚位点，化疗使用，和疾病阶段显示CRN的风险没有显着增加。
■再照射和肿瘤颅底受累是与CRN相关的重要危险因素。在CRN组中观察到较高的平均总处方和BED辐射，但这些差异没有统计学意义.性别,合并症,肿瘤亚位点，肿瘤位置,两组间治疗类型无显著差异。
■3级。
■在两个机构中确定了在18年期间诊断为鼻窦恶性肿瘤的132例患者。纳入符合纳入标准并接受放射治疗的46例患者进行分析。收集并审查了人口统计学和临床病理特征。对治疗后至少1年的治疗后磁共振成像（MRI）进行审查，以确定是否存在CRN。
■在放疗后的46例患者中有8例（17.4%）在MRI上发现CRN。有再照射史的患者更有可能发生CRN(50%vs.10.5%,p<.05)。与非CRN患者相比，CRN患者的辐射BED也较高，但这种差异并不显著(p>0.05)。CRN患者颅底受累肿瘤的比例高于非CRN患者(100%vs.57.9%,p=.037）。人口统计,合并症,病理学,原发性肿瘤亚位点，化疗使用，和疾病阶段显示CRN的风险没有显着增加。
■再照射和肿瘤颅底受累是与CRN相关的重要危险因素。在CRN组中观察到较高的平均总处方和BED辐射，但这些差异没有统计学意义.性别,合并症,肿瘤亚位点，肿瘤位置,两组间治疗类型无显著差异。
■3级。
